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pubmed-article:2138474pubmed:abstractTextWater-suppressed proton nuclear magnetic resonance spectroscopy was used to observe plasma lipoprotein lipid methyl and methylene resonances from guinea pigs which had been injected with viable or heat-killed line 1 or line 10 tumor cells or sterile oil. It was shown that the widths of these resonances became significantly sharper as the number of tumor cells grew. Plasma from tumor-free control animals showed no change in the NMR linewidths. It is concluded that the changes observed reflect a specific host response to viable tumor cells, and in these models there is a reciprocal relationship between the number of viable tumor cells and the linewidths of plasma lipoprotein methyl and methylene resonances.lld:pubmed
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pubmed-article:2138474pubmed:authorpubmed-author:DvorakH FHFlld:pubmed
pubmed-article:2138474pubmed:authorpubmed-author:FosselE TETlld:pubmed
pubmed-article:2138474pubmed:authorpubmed-author:McDonaghJJlld:pubmed
pubmed-article:2138474pubmed:authorpubmed-author:CaroJ HJHlld:pubmed
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pubmed-article:2138474pubmed:volume26lld:pubmed
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pubmed-article:2138474pubmed:pagination29-32lld:pubmed
pubmed-article:2138474pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2138474pubmed:year1990lld:pubmed
pubmed-article:2138474pubmed:articleTitleAlteration of aliphatic lipid proton NMR linewidths by malignant tumors in guinea pigs.lld:pubmed
pubmed-article:2138474pubmed:affiliationDepartment of Radiology, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.lld:pubmed
pubmed-article:2138474pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2138474pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed