| pubmed-article:21358864 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0679395 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0031638 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C1552617 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0085973 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0007320 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0282443 | lld:lifeskim |
| pubmed-article:21358864 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:21358864 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21358864 | pubmed:dateCreated | 2011-3-1 | lld:pubmed |
| pubmed-article:21358864 | pubmed:abstractText | The treatment of digital ischemia remains difficult. Sildenafil (Viagra, Pfizer UK), a selective phosphodiesterase inhibitor, increases blood flow and is currently marketed for the treatment of erectile dysfunction. A case of a 57-year-old man with progressive episodic ischemia and pain of the fingertips resulting in finger tip ulceration is presented. After failure of medical and surgical management, a trial of oral sildenafil resulted in marked symptomatic improvement of his bilateral digital ischemia. Review of the literature shows that, particularly in patients with an underlying disease such as sclero-derma with a vasospastic component, a marked improvement in digital blood flow may be observed with sildenafil use. Overall, based on a number of case reports and preliminary animal studies in the literature, sildenafil appears to have a growing significance in the treatment of hand ischemia. Similarly, there is evidence that phosphodiesterase 5 inhibitors may be used as an adjunct to improving skin flap survival. | lld:pubmed |
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| pubmed-article:21358864 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21358864 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21358864 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:21358864 | pubmed:issn | 1918-1507 | lld:pubmed |
| pubmed-article:21358864 | pubmed:author | pubmed-author:BrockGerald... | lld:pubmed |
| pubmed-article:21358864 | pubmed:author | pubmed-author:O'GormanDavid... | lld:pubmed |
| pubmed-article:21358864 | pubmed:author | pubmed-author:RosenblattYis... | lld:pubmed |
| pubmed-article:21358864 | pubmed:author | pubmed-author:Siang... | lld:pubmed |
| pubmed-article:21358864 | pubmed:author | pubmed-author:NgWendy KyWK | lld:pubmed |
| pubmed-article:21358864 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21358864 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:21358864 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21358864 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21358864 | pubmed:pagination | e5-9 | lld:pubmed |
| pubmed-article:21358864 | pubmed:dateRevised | 2011-7-26 | lld:pubmed |
| pubmed-article:21358864 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21358864 | pubmed:articleTitle | Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions. | lld:pubmed |
| pubmed-article:21358864 | pubmed:affiliation | The Hand and Upper Limb Centre; | lld:pubmed |
| pubmed-article:21358864 | pubmed:publicationType | Journal Article | lld:pubmed |
