| pubmed-article:21355532 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21355532 | lifeskim:mentions | umls-concept:C0259969 | lld:lifeskim |
| pubmed-article:21355532 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21355532 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21355532 | lifeskim:mentions | umls-concept:C0678610 | lld:lifeskim |
| pubmed-article:21355532 | lifeskim:mentions | umls-concept:C1101232 | lld:lifeskim |
| pubmed-article:21355532 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21355532 | pubmed:dateCreated | 2011-3-25 | lld:pubmed |
| pubmed-article:21355532 | pubmed:abstractText | The intramolecular 1,3-chirality transfer reaction of chiral amino alcohols 1 with 99% ee was developed to construct chiral 1-substituted tetrahydroisoquinoline 2. Bi(OTf)(3) (10 mol %)-catalyzed cyclization of 1 (R = H) afforded (S)-1-(E)-propenyl tetrahydroisoquinoline 2 (R = H) in 83% yield with a ratio of 98:2. The stereochemistry at the newly formed chiral center was produced by a syn S(N)2'-type process. In this reaction, the substituent on the benzene ring of 1 significantly affected the reactivities and selectivities. A plausible reaction mechanism was proposed. | lld:pubmed |
| pubmed-article:21355532 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21355532 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21355532 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21355532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21355532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21355532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21355532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21355532 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21355532 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21355532 | pubmed:issn | 1520-6904 | lld:pubmed |
| pubmed-article:21355532 | pubmed:author | pubmed-author:KawaiNobuyuki... | lld:pubmed |
| pubmed-article:21355532 | pubmed:author | pubmed-author:UenishiJun'ic... | lld:pubmed |
| pubmed-article:21355532 | pubmed:author | pubmed-author:MatsudaMikaM | lld:pubmed |
| pubmed-article:21355532 | pubmed:author | pubmed-author:AbeRyuzouR | lld:pubmed |
| pubmed-article:21355532 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21355532 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21355532 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:21355532 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21355532 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21355532 | pubmed:pagination | 2102-14 | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:meshHeading | pubmed-meshheading:21355532... | lld:pubmed |
| pubmed-article:21355532 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21355532 | pubmed:articleTitle | Synthesis of chiral 1-substituted tetrahydroisoquinolines by the intramolecular 1,3-chirality transfer reaction catalyzed by Bi(OTf)3. | lld:pubmed |
| pubmed-article:21355532 | pubmed:affiliation | Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8412, Japan. kawai@mb.kyoto-phu.ac.jp | lld:pubmed |
| pubmed-article:21355532 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21355532 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
