Linked Life Data

21346176

Source:http://linkedlifedata.com/resource/pubmed/id/21346176

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pubmed-article:21346176pubmed:abstractTextType 1 diabetes can be inhibited in standard NOD mice by autoantigen-specific immunotherapy targeting pathogenic CD8+ T-cells. NOD.?2m(null).HHD mice expressing human HLA-A2.1 but lacking murine major histocompatibility complex class I molecules develop diabetes characterized by CD8 T-cells recognizing certain autoantigenic peptides also targeted in human patients. These include peptides derived from the pancreatic ?-cell proteins insulin (INS1/2 A(2-10) and INS1 B(5-14)) and islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP(265-273) and IGRP(228-236)). Hence, NOD.?2m(null).HHD mice represent a model system for developing potentially clinically translatable interventions for suppressing diabetogenic HLA-A2.1-restricted T-cell responses.lld:pubmed
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pubmed-article:21346176pubmed:articleTitlePrevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.lld:pubmed
pubmed-article:21346176pubmed:affiliationJackson Laboratory, Bar Harbor, Maine, USA.lld:pubmed
pubmed-article:21346176pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21346176pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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