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pubmed-article:21338052pubmed:abstractTextPescapreins XXI-XXX (1-10), pentasaccharide resin glycosides, together with the known pescapreins I-IV and stoloniferin III were isolated from the aerial parts of Ipomoea pes-caprae (beach morning-glory). The pescapreins are macrolactones of simonic acid B, partially esterified with different fatty acids. The lactonization site of the aglycone, jalapinolic acid, was located at C-2 or C-3 of the second saccharide moiety. Their structures were established by a combination of spectroscopic and chemical methods. Compounds 1-10 were evaluated for their potential to modulate multidrug resistance in the human breast cancer cell line MCF-7/ADR. The combined use of these new compounds at a concentration of 5 ?g/mL increased the cytotoxicity of doxorubicin by 1.5-3.7-fold.lld:pubmed
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pubmed-article:21338052pubmed:articleTitlePentasaccharide resin glycosides from Ipomoea pes-caprae.lld:pubmed
pubmed-article:21338052pubmed:affiliationDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.lld:pubmed
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