| pubmed-article:21326213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21326213 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:21326213 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:21326213 | lifeskim:mentions | umls-concept:C1414119 | lld:lifeskim |
| pubmed-article:21326213 | lifeskim:mentions | umls-concept:C1540223 | lld:lifeskim |
| pubmed-article:21326213 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21326213 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:21326213 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21326213 | pubmed:dateCreated | 2011-4-6 | lld:pubmed |
| pubmed-article:21326213 | pubmed:abstractText | During antigen-specific T-cell activation, mitochondria mobilize towards the vicinity of the immune synapse. We show here that the mitochondrial fission factor dynamin-related protein 1 (Drp1) docks at mitochondria, regulating their positioning and activity near the actin-rich ring of the peripheral supramolecular activation cluster (pSMAC) of the immune synapse. Mitochondrial redistribution in response to T-cell receptor engagement was abolished by Drp1 silencing, expression of the phosphomimetic mutant Drp1S637D and the Drp1-specific inhibitor mdivi-1. Moreover, Drp1 knockdown enhanced mitochondrial depolarization and T-cell receptor signal strength, but decreased myosin phosphorylation, ATP production and T-cell receptor assembly at the central supramolecular activation cluster (cSMAC). Our results indicate that Drp1-dependent mitochondrial positioning and activity controls T-cell activation by fuelling central supramolecular activation cluster assembly at the immune synapse. | lld:pubmed |
| pubmed-article:21326213 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21326213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21326213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21326213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21326213 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21326213 | pubmed:issn | 1460-2075 | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:Sánchez-Madri... | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:SerradorJuan... | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:CarrascoYolan... | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:VeigaEstebanE | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:Martín-Cófrec... | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:MorlinoGiulia... | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:Calabia-Linar... | lld:pubmed |
| pubmed-article:21326213 | pubmed:author | pubmed-author:BaixauliFranc... | lld:pubmed |
| pubmed-article:21326213 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21326213 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:21326213 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:21326213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21326213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21326213 | pubmed:pagination | 1238-50 | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:meshHeading | pubmed-meshheading:21326213... | lld:pubmed |
| pubmed-article:21326213 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21326213 | pubmed:articleTitle | The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse. | lld:pubmed |
| pubmed-article:21326213 | pubmed:affiliation | Servicio de Inmunología, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain. | lld:pubmed |
| pubmed-article:21326213 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21326213 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7402 | entrezgene:pubmed | pubmed-article:21326213 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21326213 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21326213 | lld:pubmed |
