Linked Life Data

21325768

Source:http://linkedlifedata.com/resource/pubmed/id/21325768

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pubmed-article:21325768pubmed:abstractTextWe report here the case of an 83-year-old man who was treated for unconsciousness and hypoglycemia (39 mg/dL) accompanied by marked elevation of serum immunoreactive insulin (IRI) (4,760 µIU/mL). We diagnosed his condition as insulin autoimmune syndrome (IAS, Hirata disease) because of a high insulin autoantibody (IAA) titer (>90%: bound/total) and no history of exogenous insulin administration. Reactive hypoglycemia occurred due to immediate association followed by dissociation between insulin and insulin autoantibodies after glucose or food intake. An ?-glucosidase inhibitor in combination with frequent small meals reduced the postprandial hyperglycemia (glucose spike) and ameliorated the reactive hypoglycemia.lld:pubmed
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pubmed-article:21325768pubmed:authorpubmed-author:AngelA SASlld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:KawashimaAkir...lld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:MiyataKaoriKlld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:OkamotoYoshih...lld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:SuzukiRyokoRlld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:NakaoTaiseiTlld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:KondoMichiMlld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:NasuTetsushiTlld:pubmed
pubmed-article:21325768pubmed:authorpubmed-author:NakaoRyutaroRlld:pubmed
pubmed-article:21325768pubmed:copyrightInfo© 2011 The Japanese Society of Internal Medicinelld:pubmed
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pubmed-article:21325768pubmed:volume50lld:pubmed
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pubmed-article:21325768pubmed:pagination339-43lld:pubmed
pubmed-article:21325768pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:21325768pubmed:year2011lld:pubmed
pubmed-article:21325768pubmed:articleTitleLate postprandial hypoglycemia due to bioactive insulin dissociation from autoantibody leading to unconsciousness in a patient with insulin autoimmune syndrome.lld:pubmed
pubmed-article:21325768pubmed:affiliationDepartment of Internal Medicine, Naga Municipal Hospital, Japan. t.nasu@nagahp.jplld:pubmed
pubmed-article:21325768pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21325768pubmed:publicationTypeCase Reportslld:pubmed