| pubmed-article:21321117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0023473 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C1423033 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C2709199 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0162388 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21321117 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21321117 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:21321117 | pubmed:dateCreated | 2011-4-4 | lld:pubmed |
| pubmed-article:21321117 | pubmed:abstractText | IL-32 was recently identified as a proinflammatory cytokine that is induced by IL-18 in natural killer (NK) cells and is highly correlated with inflammatory disorders. However, the relationship between IL-32 and tumor progression is still unknown. In this study, we investigated whether overexpression of IL-32 affects susceptibility of chronic myeloid leukemia (CML) cells to NK cells. Interestingly, IL-32?-overexpressing CML cell lines, K562, Kcl22, and BV173, showed higher NK cell-mediated killing. Flow cytometry analysis revealed that overexpression of IL-32? induced increased expression of Fas and UL16-binding protein 2 (ULBP2) in CML cells. The direct relationship between overexpression of surface molecules by IL-32? and increased NK cell-mediated killing was confirmed by Fas or ULBP2 siRNA transfection. IL-32?-induced Fas and ULBP2 expression are regulated p38 MAPK. In addition, the transcription factor Ets1 plays a key role in ULBP2 specific expression by IL-32? overexpression in ULBP family members. Taken together, these data show that IL-32? stimulates Fas and ULBP2 expression via activation of p38 MAPK, which increases NK susceptibility of CML cells. Enhanced NK cell susceptibility of CML cells by IL-32? overexpression may improve the efficiency of NK cell-based immunotherapy. | lld:pubmed |
| pubmed-article:21321117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21321117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21321117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21321117 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21321117 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:YoonDo-YoungD... | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:LeeHyong... | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:LeeWang JaeWJ | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:ChoDaehoD | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:BangSa IkSI | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:ParkHyunjeong... | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:KimTaesungT | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:YoonSung-SooS... | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:ParkSunyoungS | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:MinHyeyoungH | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:CheonSoyoungS | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:LeeJi HyungJH | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:ChoByung... | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:LeeKi WoongKW | lld:pubmed |
| pubmed-article:21321117 | pubmed:author | pubmed-author:JeongSeung... | lld:pubmed |
| pubmed-article:21321117 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21321117 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:21321117 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:21321117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21321117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21321117 | pubmed:pagination | 12049-55 | lld:pubmed |
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| pubmed-article:21321117 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21321117 | pubmed:articleTitle | Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells. | lld:pubmed |
| pubmed-article:21321117 | pubmed:affiliation | Department of Life Science, Sookmyung Women's University, and Konkuk University Hospital, Seoul 140-742, Republic of Korea. | lld:pubmed |
| pubmed-article:21321117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21321117 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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