| pubmed-article:21320474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21320474 | lifeskim:mentions | umls-concept:C1512035 | lld:lifeskim |
| pubmed-article:21320474 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:21320474 | pubmed:dateCreated | 2011-3-28 | lld:pubmed |
| pubmed-article:21320474 | pubmed:abstractText | Zonisamide is an antiepileptic drug that also improves the cardinal symptoms of Parkinson's disease. This study investigated the effects of zonisamide on dopaminergic neuronal degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Six groups of mice were treated as follows: 1) normal saline; 2) MPTP, 15 mg/kg×4 every 2h; 3) MPTP and zonisamide, 40 mg/kg×1, 1h after the last MPTP dose; 4) MPTP and zonisamide, 1 day after the last dose of MPTP; 5) MPTP and zonisamide, 1h before the first MPTP dose; and 6) zonisamide, 40 mg/kg. MPTP-treatment decreased the contents of dopamine as well as the number and area of tyrosine hydroxylase (TH)-positive neurons. Concurrent treatment of mice with zonisamide and MPTP did not show any inhibition of the toxic effect of MPTP towards dopamine contents at 1 week after treatment but it increased the number and area of TH-positive neurons compared to the MPTP-treated group. Surviving TH-positive neurons had recovery of dopamine production after several weeks. Moreover, zonisamide increased the number of S100?-positive and glial fibrillary acidic protein (GFAP)-positive astrocytes and dopamine turnover. These results suggest that zonisamide acts as a neuro-protectant against MPTP-induced dopaminergic neuronal degeneration as shown by an increase of TH-positive neurons and this may be mediated by increased S100? secretion. | lld:pubmed |
| pubmed-article:21320474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21320474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21320474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21320474 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21320474 | pubmed:issn | 1872-6240 | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:NagaiMasahiro... | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:MoritoyoTakas... | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:MatsudaSeijiS | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:NomotoMasahir... | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:NishikawaNori... | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:YabeHayatoH | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:KuboMadokaM | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:ChoudhuryMoha... | lld:pubmed |
| pubmed-article:21320474 | pubmed:author | pubmed-author:KyawWin... | lld:pubmed |
| pubmed-article:21320474 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21320474 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21320474 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:21320474 | pubmed:volume | 1384 | lld:pubmed |
| pubmed-article:21320474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21320474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21320474 | pubmed:pagination | 170-8 | lld:pubmed |
| pubmed-article:21320474 | pubmed:meshHeading | pubmed-meshheading:21320474... | lld:pubmed |
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| pubmed-article:21320474 | pubmed:meshHeading | pubmed-meshheading:21320474... | lld:pubmed |
| pubmed-article:21320474 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21320474 | pubmed:articleTitle | Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity. | lld:pubmed |
| pubmed-article:21320474 | pubmed:affiliation | Department of Therapeutic Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon-Shi, Ehime 791-0295, Japan. | lld:pubmed |
| pubmed-article:21320474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21320474 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
