| pubmed-article:21317047 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21317047 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:21317047 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:21317047 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21317047 | pubmed:dateCreated | 2011-3-22 | lld:pubmed |
| pubmed-article:21317047 | pubmed:abstractText | Recombination between inverted repeats is RAD52 dependent, but reduced only modestly in the rad51? mutant. RAD59 is required for RAD51-independent inverted-repeat recombination, but no clear mechanism for how recombination occurs in the absence of RAD51 has emerged. Because Rad59 is thought to function as an accessory factor for the single-strand annealing activity of Rad52 one possible mechanism for spontaneous recombination could be by strand annealing between repeats at a stalled replication fork. Here we demonstrate the importance of the Rad52 single-strand annealing activity for generating recombinants by showing suppression of the rad52?, rad51? rad52? and rad52? rad59? inverted-repeat recombination defects by the rfa1-D228Y mutation. In addition, formation of recombinants in the rad51? mutant was sensitive to the distance between the inverted repeats, consistent with a replication-based mechanism. Deletion of RAD5 or RAD18, which are required for error-free post-replication repair, reduced the recombination rate in the rad59? mutant, but not in wild type. These data are consistent with RAD51-independent recombinants arising by a faulty template switch mechanism that is distinct from nascent strand template switching. | lld:pubmed |
| pubmed-article:21317047 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21317047 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21317047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21317047 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21317047 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21317047 | pubmed:issn | 1568-7856 | lld:pubmed |
| pubmed-article:21317047 | pubmed:author | pubmed-author:SymingtonLorr... | lld:pubmed |
| pubmed-article:21317047 | pubmed:author | pubmed-author:MottChristina... | lld:pubmed |
| pubmed-article:21317047 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21317047 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21317047 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:21317047 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:21317047 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21317047 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21317047 | pubmed:pagination | 408-15 | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:meshHeading | pubmed-meshheading:21317047... | lld:pubmed |
| pubmed-article:21317047 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21317047 | pubmed:articleTitle | RAD51-independent inverted-repeat recombination by a strand-annealing mechanism. | lld:pubmed |
| pubmed-article:21317047 | pubmed:affiliation | Department of Microbiology & Immunology, Columbia University Medical Center, 701 W. 168th St, New York, NY 10032, USA. | lld:pubmed |
| pubmed-article:21317047 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21317047 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:851266 | entrezgene:pubmed | pubmed-article:21317047 | lld:entrezgene |
| entrez-gene:854976 | entrezgene:pubmed | pubmed-article:21317047 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21317047 | lld:entrezgene |
