| pubmed-article:21316221 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0034407 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0248813 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21316221 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21316221 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21316221 | pubmed:dateCreated | 2011-3-7 | lld:pubmed |
| pubmed-article:21316221 | pubmed:abstractText | Quinazoline 3 was discovered as a novel c-jun N-terminal kinase (JNK) inhibitor with good brain penetration and pharmacokinetic (PK) properties. A number of analogs which were potent both in the biochemical and cellular assays were discovered. Quinazoline 13a was found to be a potent JNK3 inhibitor (IC(50)=40 nM), with >500-fold selectivity over p38, and had good PK and brain penetration properties. With these properties, 13a is considered a potential candidate for in vivo evaluation. | lld:pubmed |
| pubmed-article:21316221 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316221 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316221 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21316221 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316221 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21316221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21316221 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21316221 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21316221 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:JooFF | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:KameneckaTheo... | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:ChenWeiminW | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:LoGrassoPhili... | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:ShinYouseungY | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:RongJiangJ | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:HeYuanjunY | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:CameronMichae... | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:SongXinyiX | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:DuckettDerekD | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:LingYuan... | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:KoenigMarcelM | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:KhanSusanS | lld:pubmed |
| pubmed-article:21316221 | pubmed:author | pubmed-author:NoelRomainR | lld:pubmed |
| pubmed-article:21316221 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21316221 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21316221 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21316221 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21316221 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21316221 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21316221 | pubmed:pagination | 1719-23 | lld:pubmed |
| pubmed-article:21316221 | pubmed:meshHeading | pubmed-meshheading:21316221... | lld:pubmed |
| pubmed-article:21316221 | pubmed:meshHeading | pubmed-meshheading:21316221... | lld:pubmed |
| pubmed-article:21316221 | pubmed:meshHeading | pubmed-meshheading:21316221... | lld:pubmed |
| pubmed-article:21316221 | pubmed:meshHeading | pubmed-meshheading:21316221... | lld:pubmed |
| pubmed-article:21316221 | pubmed:meshHeading | pubmed-meshheading:21316221... | lld:pubmed |
| pubmed-article:21316221 | pubmed:meshHeading | pubmed-meshheading:21316221... | lld:pubmed |
| pubmed-article:21316221 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21316221 | pubmed:articleTitle | Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors. | lld:pubmed |
| pubmed-article:21316221 | pubmed:affiliation | Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #A2A, Jupiter, FL 33458, USA. | lld:pubmed |
| pubmed-article:21316221 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21316221 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21316221 | lld:chembl |
