| pubmed-article:21314671 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0073336 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21314671 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:21314671 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21314671 | pubmed:dateCreated | 2011-2-14 | lld:pubmed |
| pubmed-article:21314671 | pubmed:abstractText | We have previously shown that in Dictyostelium cells a 32 kDa protein is rapidly and completely dephosphorylated in response to starvation that is essential for the initiation of differentiation (Akiyama & Maeda 1992). In the present work, this phosphoprotein was identified as a homologue (Dd-RPS6) of ribosomal protein S6 (RPS6) that is an essential member for protein synthesis. As expected, Dd-RPS6 seems to be absolutely required for cell survival, because we failed to obtain antisense-RNA mediated cells as well as Dd-rps6-null cells by homologous recombination in spite of many trials. In many kinds of cell lines, RPS6 is known to be located in the nucleus and cytosol, but Dd-RPS6 is predominantly located in the cell cortex with cytoskeletons, and in the contractile ring of just-dividing cells. In this connection, the overexpression of Dd-RPS6 greatly impairs cytokinesis during axenic shake-cultures in growth medium, resulting in the formation of multinucleate cells. Much severe impairment of cytokinesis was observed when Dd-RPS6-overexpressing cells (Dd-RPS6(OE) cells) were incubated on a living Escherichia coli lawn. The initiation of differentiation triggered by starvation was also delayed in Dd-RPS6(OE) cells. In addition, Dd-RPS6(OE) cells exhibit defective differentiation into prespore cells and spores during late development. Thus, it is likely that the proper expression of Dd-RPS6 may be of importance for the normal progression of late differentiation as well as for the initiation of differentiation. | lld:pubmed |
| pubmed-article:21314671 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21314671 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21314671 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21314671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21314671 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21314671 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21314671 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21314671 | pubmed:issn | 1440-169X | lld:pubmed |
| pubmed-article:21314671 | pubmed:author | pubmed-author:MaedaYasuoY | lld:pubmed |
| pubmed-article:21314671 | pubmed:author | pubmed-author:AmagaiAikoA | lld:pubmed |
| pubmed-article:21314671 | pubmed:author | pubmed-author:IshiiKazutaka... | lld:pubmed |
| pubmed-article:21314671 | pubmed:author | pubmed-author:NakaoYusakuY | lld:pubmed |
| pubmed-article:21314671 | pubmed:copyrightInfo | © 2009 The Authors. Journal compilation © 2009 Japanese Society of Developmental Biologists. | lld:pubmed |
| pubmed-article:21314671 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21314671 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:21314671 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21314671 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21314671 | pubmed:pagination | 533-46 | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:meshHeading | pubmed-meshheading:21314671... | lld:pubmed |
| pubmed-article:21314671 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:21314671 | pubmed:articleTitle | Novel functions of ribosomal protein S6 in growth and differentiation of Dictyostelium cells. | lld:pubmed |
| pubmed-article:21314671 | pubmed:affiliation | Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aoba, Sendai 980-8578, Japan. | lld:pubmed |
| pubmed-article:21314671 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21314671 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:8621805 | entrezgene:pubmed | pubmed-article:21314671 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21314671 | lld:entrezgene |
