| pubmed-article:21298467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C0346647 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C0011900 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C0033522 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C2827424 | lld:lifeskim |
| pubmed-article:21298467 | lifeskim:mentions | umls-concept:C2349101 | lld:lifeskim |
| pubmed-article:21298467 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21298467 | pubmed:dateCreated | 2011-4-19 | lld:pubmed |
| pubmed-article:21298467 | pubmed:abstractText | The diagnostic utility of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer (EPC) has not been properly studied, and few reports have analysed a clinically relevant spectrum of patients. The objective was to evaluate the clinical validity of detecting K-ras mutations in the diagnosis of EPC in a large sample of clinically relevant patients. We prospectively identified 374 patients in whom one of the following diagnoses was suspected at hospital admission: EPC, chronic pancreatitis, pancreatic cysts, and cancer of the extrahepatic biliary system. Mutations in the K-ras oncogene were analysed by PCR and artificial RFLP in 212 patients. The sensitivity and specificity of the K-ras mutational status for the diagnosis of EPC were 77.7% (95% CI: 69.2-84.8) and 78.0% (68.1-86.0), respectively. The diagnostic accuracy was hardly modified by sex and age. In patients with either mutated K-ras or CEA > 5 ng/ml, the sensitivity and specificity were 81.0% (72.9-87.6) and 62.6% (72.9-87.6), respectively. In patients with mutated K-ras and CEA > 5 ng/ml the sensitivity was markedly reduced. In comparisons with a variety of non-EPC patient groups sensitivity and specificity were both always greater than 75%. In this clinically relevant sample of patients the sensitivity and specificity of K-ras mutations were not sufficiently high for independent diagnostic use. However, it seems premature to rule out the utility of K-ras analysis in conjunction with other genetic and 'omics' technologies. | lld:pubmed |
| pubmed-article:21298467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21298467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21298467 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21298467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21298467 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21298467 | pubmed:issn | 1573-7284 | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:PortaMiquelM | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:MalatsNúriaN | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:CorominasJose... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:RifàJuliJ | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:RealFrancisco... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:CarratoAlfred... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:Hernández-Agu... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:FernandezEste... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:GuarnerLuisaL | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:AlguacilJoanJ | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:ParkerLucy... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:LumbrerasBlan... | lld:pubmed |
| pubmed-article:21298467 | pubmed:author | pubmed-author:LópezTomàsT | lld:pubmed |
| pubmed-article:21298467 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21298467 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:21298467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21298467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21298467 | pubmed:pagination | 229-36 | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:meshHeading | pubmed-meshheading:21298467... | lld:pubmed |
| pubmed-article:21298467 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21298467 | pubmed:articleTitle | Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients. | lld:pubmed |
| pubmed-article:21298467 | pubmed:affiliation | Department of Public Health, Miguel Hernández University, Alicante, Spain. | lld:pubmed |
| pubmed-article:21298467 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21298467 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21298467 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| entrez-gene:3845 | entrezgene:pubmed | pubmed-article:21298467 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21298467 | lld:entrezgene |
