| pubmed-article:21297948 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0003595 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C0205372 | lld:lifeskim |
| pubmed-article:21297948 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:21297948 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21297948 | pubmed:dateCreated | 2011-2-7 | lld:pubmed |
| pubmed-article:21297948 | pubmed:abstractText | We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in A?-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. ApoE3 interacts more closely with A? than ApoE4, but a greater proportion of A? molecules within plaques are decorated with ApoE4 than ApoE3, lending strong support to the hypothesis that isoform specific differences in ApoE are linked with A? deposition. We found an increased number of ApoE N-terminal fragments in ApoE4 plaques, consistent with the observation that ApoE4 is more easily cleaved than ApoE3. In addition, we measured a small but significant isoform specific difference in ApoE domain interaction. Based on our in situ data, supported by traditional biochemical data, we propose a pathway by which isoform specific conformational differences increase the level of cleavage at the hinge region of ApoE4, leading to a loss of ApoE function to mediate clearance of A? and thereby increase the risk of AD for carriers of the APOE?4 allele. | lld:pubmed |
| pubmed-article:21297948 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21297948 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21297948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21297948 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21297948 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:HymanBradley... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:BacskaiBrian... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:HashimotoTada... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:HshiehTammy... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:JonesPhillip... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:AdamsKenneth... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:Spires-JonesT... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:RozkalneAnete... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:21297948 | pubmed:author | pubmed-author:MielkeMathewM | lld:pubmed |
| pubmed-article:21297948 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21297948 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:21297948 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21297948 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21297948 | pubmed:pagination | e14586 | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
| pubmed-article:21297948 | pubmed:meshHeading | pubmed-meshheading:21297948... | lld:pubmed |
