| pubmed-article:21296674 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C2926606 | lld:lifeskim |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:21296674 | lifeskim:mentions | umls-concept:C2607943 | lld:lifeskim |
| pubmed-article:21296674 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21296674 | pubmed:dateCreated | 2011-3-18 | lld:pubmed |
| pubmed-article:21296674 | pubmed:abstractText | The ability of anisomycin, a translation inhibitor, and actinomycin, a transcription inhibitor to disrupt a cAMP/PKA-dependent odor preference memory in neonate rat was examined. Previous reports in invertebrates had described a novel translation-dependent intermediate-term memory dissected with these inhibitors, but similar effects have not been reported in mammalian memory systems. When anisomycin was infused into the olfactory bulb after the pairing of peppermint odor and the ?-adrenoceptor agonist isoproterenol (2mg/kg), short-term memory (1 or 3h) was intact, but intermediate (5h) and long-term (24h) memory was disrupted. When actinomycin was infused, only long-term memory was disrupted. This pattern of results is consistent with that reported in invertebrates for intermediate-term memory and led us to try a lower level of the unconditioned stimulus (isoproterenol) to isolate intermediate-term memory from long-term memory. Pups given a dose of 1.5mg/kg isoproterenol paired with peppermint odor showed memory for peppermint 5h, but not 24h, after training. These observations in the rat pup olfactory system parallel short-, intermediate- and long-term memory characteristics previously described in invertebrates. Odor preference memory in neonate rodents offers a tool to increase our understanding of the properties and mechanisms of multi-phasic memory in mammals. | lld:pubmed |
| pubmed-article:21296674 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21296674 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21296674 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21296674 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21296674 | pubmed:issn | 1095-9564 | lld:pubmed |
| pubmed-article:21296674 | pubmed:author | pubmed-author:HarleyCarolyn... | lld:pubmed |
| pubmed-article:21296674 | pubmed:author | pubmed-author:McLeanJohn... | lld:pubmed |
| pubmed-article:21296674 | pubmed:author | pubmed-author:SmithMelissaM | lld:pubmed |
| pubmed-article:21296674 | pubmed:author | pubmed-author:Darby-KingAnd... | lld:pubmed |
| pubmed-article:21296674 | pubmed:author | pubmed-author:LiXuqinX | lld:pubmed |
| pubmed-article:21296674 | pubmed:author | pubmed-author:GrimesMatthew... | lld:pubmed |
| pubmed-article:21296674 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21296674 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21296674 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:21296674 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21296674 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21296674 | pubmed:pagination | 385-91 | lld:pubmed |
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| pubmed-article:21296674 | pubmed:meshHeading | pubmed-meshheading:21296674... | lld:pubmed |
| pubmed-article:21296674 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21296674 | pubmed:articleTitle | Mammalian intermediate-term memory: new findings in neonate rat. | lld:pubmed |
| pubmed-article:21296674 | pubmed:affiliation | Division of BioMedical Sciences, Memorial University of Newfoundland, St. John's, NL, Canada. | lld:pubmed |
| pubmed-article:21296674 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21296674 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
