| pubmed-article:21295539 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0315191 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0025251 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0376209 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C1515681 | lld:lifeskim |
| pubmed-article:21295539 | lifeskim:mentions | umls-concept:C0456081 | lld:lifeskim |
| pubmed-article:21295539 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21295539 | pubmed:dateCreated | 2011-3-11 | lld:pubmed |
| pubmed-article:21295539 | pubmed:abstractText | Metal ion uptake is crucial for all living cells and an essential part of cellular bioenergetic homeostasis. In this study the uptake and the impact of the most abundant internal cation, potassium, were investigated in Actinobacteria, a group of high G+C Gram-positives with a number of prominent biotechnologically and medically important members. Genome analyses revealed a variety of different potassium uptake systems in this monophyletic group ranging from potassium channels common in virtually all Actinobacteria to different active carriers that were present predominantly in pathogenic members able to cope with various stress conditions. By applying Corynebacterium glutamicum as model system we provide experimental evidence that under optimal conditions a potassium channel is sufficient in bacteria for the maintenance of internal pH and membrane potential ensuring survival of cells under stress conditions. Under potassium limitation, however, viability of C. glutamicum was increased under acidic stress or during desiccation when a functional KtrAB potassium transporter from the pathogen Corynebacterium jeikeium was heterologously expressed. We provide experimental evidence that the KtrAB mediated enhanced potassium accumulation improved maintenance of internal pH and membrane potential. The results indicate that the occurrence of active potassium transport systems correlates with an improved potassium-dependent bioenergetic homeostasis and survival of bacterial cells under stress conditions. | lld:pubmed |
| pubmed-article:21295539 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21295539 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21295539 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21295539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21295539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21295539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21295539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21295539 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21295539 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21295539 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:21295539 | pubmed:author | pubmed-author:METZK OKO | lld:pubmed |
| pubmed-article:21295539 | pubmed:author | pubmed-author:MalufF CFC | lld:pubmed |
| pubmed-article:21295539 | pubmed:author | pubmed-author:BurkovskiAndr... | lld:pubmed |
| pubmed-article:21295539 | pubmed:author | pubmed-author:KrämerReinhar... | lld:pubmed |
| pubmed-article:21295539 | pubmed:author | pubmed-author:OchrombelInes... | lld:pubmed |
| pubmed-article:21295539 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21295539 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:21295539 | pubmed:volume | 1807 | lld:pubmed |
| pubmed-article:21295539 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21295539 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21295539 | pubmed:pagination | 444-50 | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:meshHeading | pubmed-meshheading:21295539... | lld:pubmed |
| pubmed-article:21295539 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21295539 | pubmed:articleTitle | Impact of improved potassium accumulation on pH homeostasis, membrane potential adjustment and survival of Corynebacterium glutamicum. | lld:pubmed |
| pubmed-article:21295539 | pubmed:affiliation | Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany. | lld:pubmed |
| pubmed-article:21295539 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21295539 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
