Linked Life Data

21295380

Source:http://linkedlifedata.com/resource/pubmed/id/21295380

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pubmed-article:21295380pubmed:abstractTextBased on the literature-reported compensatory effect of PI3K on Abl inhibition and the improved preclinical effect of drug combination of Abl and PI3K inhibitors, a series of compounds bearing novel scaffold of (S)-3-aminopyrrolidine was identified as Abl and PI3K dual inhibitors through support vector machine screening tool, which were subsequently synthesized and tested. Most compounds demonstrated promising cytoxicity against a CML leukemia cell-line K562 and moderate inhibition against Abl and PI3K kinases. These compounds induced no apoptosis in K562 cell-line, suggesting that their cytotoxic activities are unlikely duo to other known anti-CML mechanisms. Molecular docking study further showed that the compound 5k could bind with both Abl and PI3K, but the weaker binding with Abl compared to Imatinib is consistent with its low kinase inhibitory rates. These plus literature-reported evidences suggest that the promising cytotoxic effect of our novel compounds might be due to the collective effect of Abl and PI3K inhibition.lld:pubmed
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pubmed-article:21295380pubmed:authorpubmed-author:TanChunyanClld:pubmed
pubmed-article:21295380pubmed:authorpubmed-author:ChenYuzongYlld:pubmed
pubmed-article:21295380pubmed:authorpubmed-author:JiangYuyangYlld:pubmed
pubmed-article:21295380pubmed:authorpubmed-author:MaXiaohuaXlld:pubmed
pubmed-article:21295380pubmed:authorpubmed-author:ZuXuyuXlld:pubmed
pubmed-article:21295380pubmed:authorpubmed-author:ZhangCunlongClld:pubmed
pubmed-article:21295380pubmed:authorpubmed-author:ChuBizhuBlld:pubmed
pubmed-article:21295380pubmed:copyrightInfoCopyright © 2011 Elsevier Masson SAS. All rights reserved.lld:pubmed
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pubmed-article:21295380pubmed:year2011lld:pubmed
pubmed-article:21295380pubmed:articleTitleExploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors.lld:pubmed
pubmed-article:21295380pubmed:affiliationKey Laboratory of Original New Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.lld:pubmed
pubmed-article:21295380pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21295380pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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