| pubmed-article:21280624 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C0031243 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C1517336 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21280624 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:21280624 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21280624 | pubmed:dateCreated | 2011-3-3 | lld:pubmed |
| pubmed-article:21280624 | pubmed:abstractText | A series of bay-substituted perylene derivatives is reported as a new class of G-quadruplex ligands. The synthesized compounds have differing N-cyclic substituents on the bay area and differing side chains on the perylene major axis. ESI-MS and FRET measurements highlighted the strongest quadruplex binders in this series and those showing the highest quadruplex/duplex selectivity. Several biological assays were performed on these compounds, which showed that compound 5 (PPL3C) triggered a DNA damage response in transformed cells with the formation of telomeric foci containing phosphorylated ?-H2AX and 53BP1. This effect mainly occurred in replicating cells and was consistent with Pot1 dissociation. Compound 5 does not induce telomere damage in normal cells, which are unaffected by treatment with the compound, suggesting that this agent preferentially kills cancer cells. These results reinforce the notion that G-quadruplex binding compounds can act as broad inhibitors of telomere-related processes and have potential as selective antineoplastic drugs. | lld:pubmed |
| pubmed-article:21280624 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21280624 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21280624 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280624 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21280624 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21280624 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:BiroccioAnnam... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:NeidleStephen... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:LeonettiCarlo... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:BiancoArmando... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:FranceschinMa... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:OrtaggiGianca... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:SalvatiEricaE | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:D'AngeloCarme... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:RizzoAngelaA | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:SerrilliAnna... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:CasagrandeVal... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:AlvinoAntonel... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:Ginnari-Satri... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:PorruManuelaM | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:Ciammaichella... | lld:pubmed |
| pubmed-article:21280624 | pubmed:author | pubmed-author:IachettiniSar... | lld:pubmed |
| pubmed-article:21280624 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21280624 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:21280624 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:21280624 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21280624 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21280624 | pubmed:pagination | 1140-56 | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:meshHeading | pubmed-meshheading:21280624... | lld:pubmed |
| pubmed-article:21280624 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21280624 | pubmed:articleTitle | N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. | lld:pubmed |
| pubmed-article:21280624 | pubmed:affiliation | Dipartimento di Chimica, Universita? degli Studi La Sapienza, Ple A Moro 5, 00185 Roma, Italy. | lld:pubmed |
| pubmed-article:21280624 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21280624 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21280624 | lld:chembl |
