| pubmed-article:21277964 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0085104 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0015083 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21277964 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21277964 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:21277964 | pubmed:dateCreated | 2011-4-1 | lld:pubmed |
| pubmed-article:21277964 | pubmed:abstractText | Targeted uptake of therapeutic nanoparticles in tumor cells-specific manner represents a potentially powerful technology in cancer therapy. In present study, we proposed a drug delivery system formulated with biocompatible and biodegradable cholesterol-block-poly (ethylene glycol) (Chol-PEG(2000)-COOH) polymer. And the surface of the polymer was chemically linked with truncated bFGF fragments (tbFGF). The tbFGF could recognize fibroblast growth factor receptors (FGFR) that are highly expressed by a variety of human cancer cells. The micelles had a size distribution of about 10-50 nm and significantly enhanced the cytotoxicity of paclitaxel to LL/2 cells as demonstrated by MTT test (IC??=0.21 ?g/mL for tbFGF conjugated Chol-PEG(2000)-COOH micelles (tbFGF-M-PTX) versus 26.43 ?g/mL for free paclitaxel, respectively). Flow cytometry revealed the cellular uptake of rhodamine B encapsulated in the tbFGF-conjugated micelles was increased by 6.6-fold for HepG2, 6.2-fold for A549, 2.9-fold for C26 and 2.7-fold for LL/2 tumor cells, respectively, compared with micelles without tbFGF. The fluorescence spectroscopy images further demonstrated that the tbFGF conjugated micelles could specifically bind to the tumor cells that over-expressed FGFRs and then release rhodamine B into the cytoplasm. Our results suggest the tbFGF conjugated Chol-PEG(2000)-COOH micelles have great potential application for tumor targeting therapy. | lld:pubmed |
| pubmed-article:21277964 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21277964 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21277964 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21277964 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21277964 | pubmed:issn | 1873-3476 | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:MiaoZ MZM | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:FuZ HZH | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:KatenD MDM | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:YangLiL | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:WeiYuquanY | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:ChenXiangX | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:ARR | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:ChenLijuanL | lld:pubmed |
| pubmed-article:21277964 | pubmed:author | pubmed-author:CaiLuluL | lld:pubmed |
| pubmed-article:21277964 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21277964 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21277964 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21277964 | pubmed:volume | 408 | lld:pubmed |
| pubmed-article:21277964 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21277964 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21277964 | pubmed:pagination | 173-82 | lld:pubmed |
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| pubmed-article:21277964 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21277964 | pubmed:articleTitle | A novel truncated basic fibroblast growth factor fragment-conjugated poly (ethylene glycol)-cholesterol amphiphilic polymeric drug delivery system for targeting to the FGFR-overexpressing tumor cells. | lld:pubmed |
| pubmed-article:21277964 | pubmed:affiliation | State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of China. | lld:pubmed |
| pubmed-article:21277964 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21277964 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
