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pubmed-article:21277936pubmed:abstractTextRationally designed therapies aim at the specific disruption of critical signaling pathways activated by malignant transformation or signals from the tumor microenvironment. Because mammalian target of rapamycin (mTOR) is an important signal integrator and a key translational regulator, we evaluated its potential involvement in T-cell acute lymphoblastic leukemia (T-ALL) and whether mTOR blockade synergizes with chemotherapeutic agents or other signaling antagonists to inhibit primary leukemia T cells.lld:pubmed
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pubmed-article:21277936pubmed:copyrightInfoCopyright © 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.lld:pubmed
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pubmed-article:21277936pubmed:articleTitleTargeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors.lld:pubmed
pubmed-article:21277936pubmed:affiliationDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Mass., USA.lld:pubmed
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