| pubmed-article:21270956 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21270956 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:21270956 | lifeskim:mentions | umls-concept:C0087178 | lld:lifeskim |
| pubmed-article:21270956 | lifeskim:mentions | umls-concept:C0205094 | lld:lifeskim |
| pubmed-article:21270956 | lifeskim:mentions | umls-concept:C0876926 | lld:lifeskim |
| pubmed-article:21270956 | lifeskim:mentions | umls-concept:C0598179 | lld:lifeskim |
| pubmed-article:21270956 | lifeskim:mentions | umls-concept:C0025265 | lld:lifeskim |
| pubmed-article:21270956 | pubmed:dateCreated | 2011-1-28 | lld:pubmed |
| pubmed-article:21270956 | pubmed:abstractText | In this fMRI study, the functions of the anterior cingulate cortex (ACC) were studied in a group of adolescents who had sustained a moderate to severe traumatic brain injury (TBI). A spatial working memory task with varying working memory loads, representing experimental conditions of increasing difficulty, was administered. In a cross-sectional comparison between the patients and a matched control group, patients performed worse than Controls, showing longer reaction times and lower response accuracy on the spatial working memory task. Brain imaging findings suggest a possible double-dissociation: activity of the ACC in the TBI group, but not in the Control group, was associated with task difficulty; conversely, activity of the left sensorimotor cortex (lSMC) in the Control group, but not in the TBI group, was correlated with task difficulty. In addition to the main cross-sectional study, a longitudinal study of a group of adolescent patients with moderate to severe TBI was done using fMRI and the same spatial working memory task. The patient group was studied at two time-points: one time-point during the post-acute phase and one time-point 12 months later, during the chronic phase. Results indicated that patients' behavioral performance improved over time, suggesting cognitive recovery. Brain imaging findings suggest that, over this 12-month period, patients recruited less of the ACC and more of the lSMC in response to increasing task difficulty. The role of ACC in executive functions following a moderate to severe brain injury in adolescence is discussed within the context of conflicting models of the ACC functions in the existing literature. | lld:pubmed |
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| pubmed-article:21270956 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21270956 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21270956 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:21270956 | pubmed:issn | 1664-2295 | lld:pubmed |
| pubmed-article:21270956 | pubmed:author | pubmed-author:AsarnowRobert... | lld:pubmed |
| pubmed-article:21270956 | pubmed:author | pubmed-author:BabikianTalin... | lld:pubmed |
| pubmed-article:21270956 | pubmed:author | pubmed-author:HovdaDavidD | lld:pubmed |
| pubmed-article:21270956 | pubmed:author | pubmed-author:CazalisFabien... | lld:pubmed |
| pubmed-article:21270956 | pubmed:author | pubmed-author:CopelandSarah... | lld:pubmed |
| pubmed-article:21270956 | pubmed:author | pubmed-author:GizaChristoph... | lld:pubmed |
| pubmed-article:21270956 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21270956 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:21270956 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21270956 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21270956 | pubmed:pagination | 158 | lld:pubmed |
| pubmed-article:21270956 | pubmed:dateRevised | 2011-7-21 | lld:pubmed |
| pubmed-article:21270956 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21270956 | pubmed:articleTitle | Pivotal role of anterior cingulate cortex in working memory after traumatic brain injury in youth. | lld:pubmed |
| pubmed-article:21270956 | pubmed:affiliation | Psychiatry and Biobehavioral Sciences, University of California Los Angeles David Geffen School of Medicine Los Angeles, CA, USA. | lld:pubmed |
| pubmed-article:21270956 | pubmed:publicationType | Journal Article | lld:pubmed |
