| pubmed-article:21270895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21270895 | lifeskim:mentions | umls-concept:C0684063 | lld:lifeskim |
| pubmed-article:21270895 | lifeskim:mentions | umls-concept:C0008810 | lld:lifeskim |
| pubmed-article:21270895 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:21270895 | pubmed:issue | 7331 | lld:pubmed |
| pubmed-article:21270895 | pubmed:dateCreated | 2011-1-28 | lld:pubmed |
| pubmed-article:21270895 | pubmed:abstractText | Circadian rhythms are ubiquitous in eukaryotes, and coordinate numerous aspects of behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and photosynthesis in plants. This daily timekeeping is thought to be driven by transcriptional-translational feedback loops, whereby rhythmic expression of 'clock' gene products regulates the expression of associated genes in approximately 24-hour cycles. The specific transcriptional components differ between phylogenetic kingdoms. The unicellular pico-eukaryotic alga Ostreococcus tauri possesses a naturally minimized clock, which includes many features that are shared with plants, such as a central negative feedback loop that involves the morning-expressed CCA1 and evening-expressed TOC1 genes. Given that recent observations in animals and plants have revealed prominent post-translational contributions to timekeeping, a reappraisal of the transcriptional contribution to oscillator function is overdue. Here we show that non-transcriptional mechanisms are sufficient to sustain circadian timekeeping in the eukaryotic lineage, although they normally function in conjunction with transcriptional components. We identify oxidation of peroxiredoxin proteins as a transcription-independent rhythmic biomarker, which is also rhythmic in mammals. Moreover we show that pharmacological modulators of the mammalian clock mechanism have the same effects on rhythms in Ostreococcus. Post-translational mechanisms, and at least one rhythmic marker, seem to be better conserved than transcriptional clock regulators. It is plausible that the oldest oscillator components are non-transcriptional in nature, as in cyanobacteria, and are conserved across kingdoms. | lld:pubmed |
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| pubmed-article:21270895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21270895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21270895 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21270895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21270895 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21270895 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:MillarAndrew... | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:ReddyAkhilesh... | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:TroeinCarlC | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:O'NeillJohn... | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:CorellouFlore... | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:BougetFrançoi... | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:21270895 | pubmed:author | pubmed-author:DixonLaura... | lld:pubmed |
| pubmed-article:21270895 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21270895 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:21270895 | pubmed:volume | 469 | lld:pubmed |
| pubmed-article:21270895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21270895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21270895 | pubmed:pagination | 554-8 | lld:pubmed |
| pubmed-article:21270895 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:21270895 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21270895 | pubmed:articleTitle | Circadian rhythms persist without transcription in a eukaryote. | lld:pubmed |
| pubmed-article:21270895 | pubmed:affiliation | Centre for Systems Biology at Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK. | lld:pubmed |
| pubmed-article:21270895 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21270895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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