| pubmed-article:21269824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C1417825 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C1421546 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C2698650 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21269824 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:21269824 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21269824 | pubmed:dateCreated | 2011-2-7 | lld:pubmed |
| pubmed-article:21269824 | pubmed:abstractText | Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts culminated in the discovery of 4-{(S)-2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid 7g, a highly potent and selective FXR agonist with excellent physicochemical and ADME properties and potent lipid lowering activity after oral administration to LDL receptor deficient mice. | lld:pubmed |
| pubmed-article:21269824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21269824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21269824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21269824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21269824 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21269824 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:TaylorSS | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:BlumDD | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:HartmanPP | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:KuhnBB | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:BensonG MGM | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:MartinR ERE | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:GretherUU | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:SchulerFF | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:FengSS | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:GardelJJ | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:ClemannNN | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:ChaputEE | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:RudolphM GMG | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:RichterHans... | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:PlancherJ-MJM | lld:pubmed |
| pubmed-article:21269824 | pubmed:author | pubmed-author:BleicherK HKH | lld:pubmed |
| pubmed-article:21269824 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21269824 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21269824 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21269824 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21269824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21269824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21269824 | pubmed:pagination | 1134-40 | lld:pubmed |
| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
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| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
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| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
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| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
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| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
| pubmed-article:21269824 | pubmed:meshHeading | pubmed-meshheading:21269824... | lld:pubmed |
| pubmed-article:21269824 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21269824 | pubmed:articleTitle | Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties. | lld:pubmed |
| pubmed-article:21269824 | pubmed:affiliation | F. Hoffmann-La Roche Ltd, Pharmaceutical Research, Grenzacherstrasse, CH-4070 Basel, Switzerland. hans.richter@roche.com | lld:pubmed |
| pubmed-article:21269824 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21269824 | lld:chembl |
