| pubmed-article:21266577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21266577 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:21266577 | lifeskim:mentions | umls-concept:C0027021 | lld:lifeskim |
| pubmed-article:21266577 | lifeskim:mentions | umls-concept:C0740394 | lld:lifeskim |
| pubmed-article:21266577 | lifeskim:mentions | umls-concept:C0935936 | lld:lifeskim |
| pubmed-article:21266577 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:21266577 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:21266577 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:21266577 | pubmed:dateCreated | 2011-4-11 | lld:pubmed |
| pubmed-article:21266577 | pubmed:abstractText | Urate and myeloperoxidase (MPO) are associated with adverse outcomes in cardiovascular disease. In this study, we assessed whether urate is a likely physiological substrate for MPO and if the products of their interaction have the potential to exacerbate inflammation. Urate was readily oxidized by MPO and hydrogen peroxide to 5-hydroxyisourate, which decayed to predominantly allantoin. The redox intermediates of MPO were reduced by urate with rate constants of 4.6 × 10(5) M(-1) s(-1) for compound I and 1.7 × 10(4) M(-1) s(-1) for compound II. Urate competed with chloride for oxidation by MPO and at hyperuricemic levels is expected to be a substantive substrate for the enzyme. Oxidation of urate promoted super-stoichiometric consumption of glutathione, which indicates that it is converted to a free radical intermediate. In combination with superoxide and hydrogen peroxide, MPO oxidized urate to a reactive hydroperoxide. This would form by addition of superoxide to the urate radical. Urate also enhanced MPO-dependent consumption of nitric oxide. In human plasma, stimulated neutrophils produced allantoin in a reaction dependent on the NADPH oxidase, MPO and superoxide. We propose that urate is a physiological substrate for MPO that is oxidized to the urate radical. The reactions of this radical with superoxide and nitric oxide provide a plausible link between urate and MPO in cardiovascular disease. | lld:pubmed |
| pubmed-article:21266577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21266577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21266577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21266577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21266577 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21266577 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:KettleAnthony... | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:ThomasShane... | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:ReesMartin... | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:JamesonGuy... | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:TurnerRufusR | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:HarwoodD... | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:MeottiFlavia... | lld:pubmed |
| pubmed-article:21266577 | pubmed:author | pubmed-author:StockwellSama... | lld:pubmed |
| pubmed-article:21266577 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21266577 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21266577 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:21266577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21266577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21266577 | pubmed:pagination | 12901-11 | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
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| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:meshHeading | pubmed-meshheading:21266577... | lld:pubmed |
| pubmed-article:21266577 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21266577 | pubmed:articleTitle | Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation. | lld:pubmed |
| pubmed-article:21266577 | pubmed:affiliation | Free Radical Research Group, Department of Pathology, University of Otago, P. O. Box 4345, 8140 Christchurch, New Zealand. | lld:pubmed |
| pubmed-article:21266577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21266577 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
