| pubmed-article:21257967 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:21257967 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:21257967 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21257967 | pubmed:dateCreated | 2011-2-17 | lld:pubmed |
| pubmed-article:21257967 | pubmed:abstractText | Although many studies have shown that pulmonary surfactant protein (SP)-A functions in innate immunity, fewer studies have addressed its role in adaptive immunity and allergic hypersensitivity. We hypothesized that SP-A modulates the phenotype and prevalence of dendritic cells (DCs) and CD4(+) T cells to inhibit Th2-associated inflammatory indices associated with allergen-induced inflammation. In an OVA model of allergic hypersensitivity, SP-A(-/-) mice had greater eosinophilia, Th2-associated cytokine levels, and IgE levels compared with wild-type counterparts. Although both OVA-exposed groups had similar proportions of CD86(+) DCs and Foxp3(+) T regulatory cells, the SP-A(-/-) mice had elevated proportions of CD4(+) activated and effector memory T cells in their lungs compared with wild-type mice. Ex vivo recall stimulation of CD4(+) T cell pools demonstrated that cells from the SP-A(-/-) OVA mice had the greatest proliferative and IL-4-producing capacity, and this capability was attenuated with exogenous SP-A treatment. Additionally, tracking proliferation in vivo demonstrated that CD4(+) activated and effector memory T cells expanded to the greatest extent in the lungs of SP-A(-/-) OVA mice. Taken together, our data suggested that SP-A influences the prevalence, types, and functions of CD4(+) T cells in the lungs during allergic inflammation and that SP deficiency modifies the severity of inflammation in allergic hypersensitivity conditions like asthma. | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21257967 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21257967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21257967 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21257967 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21257967 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:SempowskiGreg... | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:WrightJo... | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:MukherjeeSamb... | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:LoBerniceB | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:FrancoKathy... | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:PastvaAmy MAM | lld:pubmed |
| pubmed-article:21257967 | pubmed:author | pubmed-author:Giamberardino... | lld:pubmed |
| pubmed-article:21257967 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21257967 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21257967 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:21257967 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21257967 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21257967 | pubmed:pagination | 2842-9 | lld:pubmed |
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| pubmed-article:21257967 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21257967 | pubmed:articleTitle | Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation. | lld:pubmed |
| pubmed-article:21257967 | pubmed:affiliation | Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. | lld:pubmed |
| pubmed-article:21257967 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21257967 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21257967 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:20387 | entrezgene:pubmed | pubmed-article:21257967 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21257967 | lld:entrezgene |
