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pubmed-article:21257780pubmed:abstractTextChicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because ligands for COUP-TFs have yet to be identified. Since 1998, extensive studies have demonstrated their physiological importance in cell-fate specification, organogenesis, angiogenesis, and metabolism, as well as a variety of diseases. In this article, we will comprehensively review the biological functions of COUP-TFII and its underlying mechanism in various developmental processes and diseases. In addition, we will briefly summarize some of the current findings of COUP-TFI.lld:pubmed
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pubmed-article:21257780pubmed:year2011lld:pubmed
pubmed-article:21257780pubmed:articleTitleCoup d'Etat: an orphan takes control.lld:pubmed
pubmed-article:21257780pubmed:affiliationDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Texas 77030, USA. mtsai@bcm.edulld:pubmed
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