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pubmed-article:21257722pubmed:abstractTextSphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is catalyzed by sphingosine kinase 1 (SphK). Safingol, (l-threo-dihydrosphingosine) is a putative inhibitor of SphK. We conducted a phase I trial of safingol (S) alone and in combination with cisplatin (C).lld:pubmed
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pubmed-article:21257722pubmed:articleTitleA phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.lld:pubmed
pubmed-article:21257722pubmed:affiliationMelanoma and Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.lld:pubmed
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