| pubmed-article:21255825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C0010723 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C2350332 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C1421876 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C1704973 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:21255825 | lifeskim:mentions | umls-concept:C0449435 | lld:lifeskim |
| pubmed-article:21255825 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21255825 | pubmed:dateCreated | 2011-2-7 | lld:pubmed |
| pubmed-article:21255825 | pubmed:abstractText | Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphocytes by deaminating cytidines on template and nontemplate strands of transcribed DNA substrates. However, the mechanism of AID access to the template DNA strand, particularly when hybridized to a nascent RNA transcript, has been an enigma. We now implicate the RNA exosome, a cellular RNA-processing/degradation complex, in targeting AID to both DNA strands. In B lineage cells activated for CSR, the RNA exosome associates with AID, accumulates on IgH switch regions in an AID-dependent fashion, and is required for optimal CSR. Moreover, both the cellular RNA exosome complex and a recombinant RNA exosome core complex impart robust AID- and transcription-dependent DNA deamination of both strands of transcribed SHM substrates in vitro. Our findings reveal a role for noncoding RNA surveillance machinery in generating antibody diversity. | lld:pubmed |
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| pubmed-article:21255825 | pubmed:language | eng | lld:pubmed |
