| pubmed-article:21253713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21253713 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21253713 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:21253713 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:21253713 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:21253713 | lifeskim:mentions | umls-concept:C2698872 | lld:lifeskim |
| pubmed-article:21253713 | lifeskim:mentions | umls-concept:C0559956 | lld:lifeskim |
| pubmed-article:21253713 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21253713 | pubmed:dateCreated | 2011-3-18 | lld:pubmed |
| pubmed-article:21253713 | pubmed:abstractText | Growth hormone (GH) replacement in adulthood results in variable bone responses as a function of the gonadic hormonal milieu. We performed a retrospective analysis of a large cohort of adult males and females with confirmed GH deficiency (GHD) prior to treatment and during 3 years of replacement therapy. Potential confounders and effect modifiers were taken into account. Sixty-four adult patients with GHD (20 females and 44 males; mean age 34 years, range 18-64) were included in the analysis. GH replacement induced a different effect on bone in males compared to females. Bone mineral content increased in males and decreased in females at the lumbar spine, total femur, and femoral neck; bone mineral density showed a similar trend at the lumbar spine and femoral neck. There was no significant gender difference in bone area at any measured bone site. In both sexes we observed a similar trend for serum markers of bone remodeling. Sex predicted bone outcome on multivariate analysis, as did age, onset of GHD (childhood/adulthood), pretreatment bone mass, baseline body mass index (BMI), and BMI change during GH replacement. Serum IGF-I levels during treatment did not show any relationship with bone outcome at any measured site. This study confirms that bone responsiveness to GH replacement in adult GHD varies as a function of sex even after controlling for potential confounders and highlights the importance of other cofactors that may affect the interaction between GH replacement therapy and bone remodeling. | lld:pubmed |
| pubmed-article:21253713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21253713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21253713 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21253713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21253713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21253713 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21253713 | pubmed:issn | 1432-0827 | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:LosaMarcoM | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:ScaviniMarina... | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:RubinacciAles... | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:LanziRobertoR | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:VillaIsabella... | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:GattiElisaE | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:SirtoriMarcel... | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:RossiniAlessa... | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:MadaschiSaraS | lld:pubmed |
| pubmed-article:21253713 | pubmed:author | pubmed-author:MolinariChiar... | lld:pubmed |
| pubmed-article:21253713 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21253713 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:21253713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21253713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21253713 | pubmed:pagination | 304-13 | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:meshHeading | pubmed-meshheading:21253713... | lld:pubmed |
| pubmed-article:21253713 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21253713 | pubmed:articleTitle | Predictors of bone responsiveness to growth hormone (GH) replacement in adult GH-deficient patients. | lld:pubmed |
| pubmed-article:21253713 | pubmed:affiliation | Endocrinology Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy. | lld:pubmed |
| pubmed-article:21253713 | pubmed:publicationType | Journal Article | lld:pubmed |
