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pubmed-article:21251280pubmed:abstractTextGlucagon-like peptide-1 (GLP-1) is a hormone predominately synthesized and secreted by intestinal L-cells. GLP-1 modulates multiple cellular functions and its receptor agonists are now used clinically for diabetic treatment. Interestingly, preclinical and clinical evidence suggests that GLP-1 agonists produce beneficial effects on dysfunctional hearts via acting on myocardial GLP-1 receptors. As the effects of GLP-1 on myocyte electrophysiology are largely unknown, this study was to assess if GLP-1 could affect the cardiac voltage-gated L-type Ca2+ current (I(Ca)).lld:pubmed
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pubmed-article:21251280pubmed:authorpubmed-author:XiaoYong-FuYFlld:pubmed
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pubmed-article:21251280pubmed:articleTitleGlucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway.lld:pubmed
pubmed-article:21251280pubmed:affiliationCardiac Rhythm Disease Management, Medtronic, Inc., 8200 Coral Sea Street NE, Mounds View, MN 55112, USA. yong-fu.xiao@medtronic.comlld:pubmed
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