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pubmed-article:21250544pubmed:abstractTextThe African malaria mosquito Anopheles gambiae was the first disease vector chosen for genome sequencing. Although its genome assembly has been facilitated by physical mapping, large gaps still pose a serious problem for accurate annotation and genome analysis. The majority of the gaps are located in regions of pericentromeric and intercalary heterochromatin. Genomic analysis has identified protein-coding genes and various classes of repetitive elements in the Anopheles heterochromatin. Molecular and cytogenetic studies have demonstrated that heterochromatin is a structurally heterogeneous and rapidly evolving part of the malaria mosquito genome.lld:pubmed
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pubmed-article:21250544pubmed:articleTitleOrganization and evolution of heterochromatin in malaria mosquitoes.lld:pubmed
pubmed-article:21250544pubmed:affiliationDepartment of Entomology, Fralin Life Science Institute, Virginia Tech, Blacksburg, VA 24061, USA. msharakh@vt.edulld:pubmed
pubmed-article:21250544pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21250544pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed