| pubmed-article:2124252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C0241526 | lld:lifeskim |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2124252 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2124252 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2124252 | pubmed:dateCreated | 1991-1-31 | lld:pubmed |
| pubmed-article:2124252 | pubmed:abstractText | Highly purified, small dense splenic B cells from unstimulated mice showed increased expression of class II major histocompatibility complex (MHC) antigens and enhanced viability when cultured with affinity-purified recombinant interleukin 10 (rIL-10), compared with B cells cultured in medium alone. These responses were blocked by a monoclonal antibody (mAb) specific for IL-10, but not by an isotype-matched control antibody. IL-10 did not upregulate the expression of Fc epsilon receptors (CD23) or class I MHC antigens on small dense B cells or induce their replication as monitored by [3H]thymidine incorporation. While these B cell-stimulatory properties of IL-10 are also mediated by IL-4, the two cytokines appear to act independently in these assays; anti-IL-10 antibodies blocked IL-10 but not IL-4-mediated B cell viability enhancement, and vice versa. Similarly, since IL-4 upregulates CD23 on small dense B cells, the inability of IL-10 to do so argues against its acting via endogenously generated IL-4. Finally, IL-10 did not upregulate class II MHC antigens on B cells from X chromosome-linked immunodeficiency (XID) mice, while the same cells showed normal upregulation of class II antigens in response to IL-4. This report also extends our understanding of the relationship between IL-10 and the highly homologous Epstein-Barr virus (EBV)-encoded Bam HI fragment C rightward reading frame no. 1 (BCRFI) protein. It has previously been shown that BCRFI protein exhibits the cytokine synthesis inhibitory activity of IL-10. This report indicates that BCRFI protein also enhances in vitro B cell viability, but does not upregulate class II MHC antigens on B cells. One explanation for these data is that IL-10 contains at least two functional epitopes, only one of which has been conserved by EBV. | lld:pubmed |
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| pubmed-article:2124252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2124252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2124252 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2124252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2124252 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2124252 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:HowardMM | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:BarrettRR | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:MosmannT RTR | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:MooreK WKW | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:ECOTBB | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:KasteleinRR | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:CastleB EBE | lld:pubmed |
| pubmed-article:2124252 | pubmed:author | pubmed-author:GoN FNF | lld:pubmed |
| pubmed-article:2124252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2124252 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2124252 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:2124252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2124252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2124252 | pubmed:pagination | 1625-31 | lld:pubmed |
| pubmed-article:2124252 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2124252 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2124252 | pubmed:articleTitle | Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. | lld:pubmed |
| pubmed-article:2124252 | pubmed:affiliation | DNAX Research Institute of Molecular and Cellular Biology, Inc., Palo Alto, California 94304. | lld:pubmed |
| pubmed-article:2124252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2124252 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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