Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:212421rdf:typepubmed:Citationlld:pubmed
pubmed-article:212421lifeskim:mentionsumls-concept:C0034493lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C0035286lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C0027270lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C0021467lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C1883254lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C1948023lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:212421lifeskim:mentionsumls-concept:C1522240lld:lifeskim
pubmed-article:212421pubmed:issue20lld:pubmed
pubmed-article:212421pubmed:dateCreated1978-12-27lld:pubmed
pubmed-article:212421pubmed:abstractTextNAD+ at 0.16 mM stimulates the initiation step of the protein synthetic process in lysed rabbit reticulocytes. This conclusion is based on the stimulation of (i) the transfer of formylmethionine from f[35S]Met-tRNAfMet into polypeptide, (ii) the accumulation of the initial dipeptide, methionylvaline, in the presence of pactamycin, and (iii) the formation of the 40 S initiation complex. The effect of NAD+ changes from a stimulatory role on protein synthesis to an inhibitory role at concentrations greater than 0.16 mM. At 4.0 mM NAD+, protein synthesis is inhibited. This has been demonstrated experimentally by using the same three assays described above. In addition, 4.0 mM NAD+ inhibits MettRNAfMet.initiation factor.GTP ternary complex formation. The elongation and termination steps of polypeptide synthesis are not affected by 0.16 to 4.0 mM NAD+. The data presented clearly show that the stimulatory activity of 0.16 mM NAD+ and the inhibitory activity of 4.0 mM NAD+ affects the initiation step of the protein synthetic process in lysed rabbit reticulocytes.lld:pubmed
pubmed-article:212421pubmed:languageenglld:pubmed
pubmed-article:212421pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:212421pubmed:citationSubsetIMlld:pubmed
pubmed-article:212421pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:212421pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:212421pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:212421pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:212421pubmed:statusMEDLINElld:pubmed
pubmed-article:212421pubmed:monthOctlld:pubmed
pubmed-article:212421pubmed:issn0021-9258lld:pubmed
pubmed-article:212421pubmed:authorpubmed-author:WuJ MJMlld:pubmed
pubmed-article:212421pubmed:authorpubmed-author:SuhadolnikR...lld:pubmed
pubmed-article:212421pubmed:authorpubmed-author:CheungC PCPlld:pubmed
pubmed-article:212421pubmed:issnTypePrintlld:pubmed
pubmed-article:212421pubmed:day25lld:pubmed
pubmed-article:212421pubmed:volume253lld:pubmed
pubmed-article:212421pubmed:ownerNLMlld:pubmed
pubmed-article:212421pubmed:authorsCompleteYlld:pubmed
pubmed-article:212421pubmed:pagination7295-300lld:pubmed
pubmed-article:212421pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-A...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-B...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-M...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-R...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-K...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-R...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-N...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-R...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-P...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-P...lld:pubmed
pubmed-article:212421pubmed:meshHeadingpubmed-meshheading:212421-P...lld:pubmed
pubmed-article:212421pubmed:year1978lld:pubmed
pubmed-article:212421pubmed:articleTitleStimulation and inhibition of the protein synthetic process by NAD+ in lysed rabbit reticulocytes.lld:pubmed
pubmed-article:212421pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:212421pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed