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pubmed-article:21241463pubmed:abstractTextHepatocellular carcinoma (HCC) is the fifth most common neoplasia in the world. In the past, treatment of advanced HCC with conventional antineoplastic drugs did not result in satisfactory outcomes: recently, in this patient population the oral multikinase inhibitor sorafenib has been able to induce a statistically significant improvement of overall survival. Similarly to other anti-angiogenic drugs employed in other tumour types, also sorafenib seldom induces the dimensional tumour shrinking usually observed with conventional cytotoxic drugs: data gathered from studies carried out with sorafenib and other competitors under development do not report any complete response in HCV-induced HCC.lld:pubmed
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pubmed-article:21241463pubmed:articleTitleComplete response for advanced liver cancer during sorafenib therapy: case report.lld:pubmed
pubmed-article:21241463pubmed:affiliationGastroenterology Department, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy. saccorodolfo@hotmail.comlld:pubmed
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