| pubmed-article:21239607 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21239607 | lifeskim:mentions | umls-concept:C0032285 | lld:lifeskim |
| pubmed-article:21239607 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21239607 | lifeskim:mentions | umls-concept:C0016059 | lld:lifeskim |
| pubmed-article:21239607 | lifeskim:mentions | umls-concept:C0672553 | lld:lifeskim |
| pubmed-article:21239607 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21239607 | pubmed:dateCreated | 2011-9-7 | lld:pubmed |
| pubmed-article:21239607 | pubmed:abstractText | Oxidative stress plays an important role in the pathogenesis of acute lung injury and pulmonary fibrosis. Peroxiredoxin (Prx) I is a cellular antioxidant enzyme induced under stress conditions. In the present study, the protective effects of Prx I on the development of bleomycin-induced acute pulmonary inflammation and pulmonary fibrosis were investigated using Prx I-deficient mice. Survival of Prx I-deficient mice after bleomycin administration was significantly lower than that of wild-type mice, corresponding with enhanced acute pulmonary inflammation and fibrosis. The level of inflammatory cytokines and chemokines, such as TNF-?, macrophage inflammatory protein-2, and monocyte chemotactic protein-1, was significantly elevated in the bronchoalveolar lavage fluid of Prx I-deficient mice after bleomycin administration. Furthermore, the level of 8-isoprostane, an oxidative stress marker, and the concentration and alveolar macrophage expression of macrophage migration inhibitory factor were elevated in the lungs of Prx I-deficient mice after bleomycin administration. The exacerbation of bleomycin-induced pulmonary inflammation and fibrosis in Prx I-deficient mice was inhibited by treatment with N-acetyl-L-cysteine, a radical scavenger, or with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester, a tautomerase inhibitor of macrophage migration inhibitory factor. These findings suggest that mice lacking Prx I are highly susceptible to bleomycin-induced pulmonary inflammation and fibrosis because of increases in pulmonary oxidant levels and macrophage migration inhibitory factor activity in response to bleomycin. | lld:pubmed |
| pubmed-article:21239607 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21239607 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21239607 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21239607 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21239607 | pubmed:issn | 1535-4989 | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:SakamotoTohru... | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:IshiiYukioY | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:MorishimaYuko... | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:IshiiTetsuroT | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:YanagawaToruT | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:KikuchiNorihi... | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:HizawaNobuyuk... | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:WarabiEijiE | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:HaraguchiNori... | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:YagetaYuichiY | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:YamadoriTadah... | lld:pubmed |
| pubmed-article:21239607 | pubmed:author | pubmed-author:MasukoHironor... | lld:pubmed |
| pubmed-article:21239607 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21239607 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:21239607 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21239607 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21239607 | pubmed:pagination | 600-9 | lld:pubmed |
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| pubmed-article:21239607 | pubmed:meshHeading | pubmed-meshheading:21239607... | lld:pubmed |
| pubmed-article:21239607 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21239607 | pubmed:articleTitle | Aggravation of bleomycin-induced pulmonary inflammation and fibrosis in mice lacking peroxiredoxin I. | lld:pubmed |
| pubmed-article:21239607 | pubmed:affiliation | Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan. | lld:pubmed |
| pubmed-article:21239607 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21239607 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21239607 | lld:entrezgene |
