| pubmed-article:21236472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C0012739 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C0016017 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C0064833 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C0015982 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:21236472 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:21236472 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21236472 | pubmed:dateCreated | 2011-3-22 | lld:pubmed |
| pubmed-article:21236472 | pubmed:abstractText | An alternative pathway for fibrinolysis that comprises leukocyte elastase and its interaction with the plasminogen activator-plasmin system has been suggested. Plasma levels of cross-linked fibrin degradation product by leukocyte elastase (e-XDP) were significantly increased in patients with sepsis induced disseminated intravascular coagulation (DIC) compared with healthy subjects (18.6±19.9 vs 0.58±0.47U/mL, p<0.001). Twenty seven unique spots were identified from e-XDP dominant patients by immune-purification and two-dimensional difference gel electrophoresis, and they contained fibrinogen B?-chain derived fragments B? Asp-164, Ser-200, Gln-301, Ala-354, Ile-484 and ?-chain derivatives ? Val-274 at their amino-termini by acquired and processed tandem mass spectrometer. The Sequential Organ Failure Assessment Scores in patients with e-XDPs levels 3-10U/mL were significantly lower than those with e-XDPs levels -3U/mL, 10-30U/mL, and 30- U/mL. The adjusted odds for 28-day mortality rate in patients with e-XDP levels less than 3U/mL (hazard ratio, 4.432; 95% CI, 1.557-12.615 [p=0.005]) were significantly higher than those in patients with e-XDP levels of 3-10U/mL. These data suggest that leukocyte elastase might contribute to the degradation of cross-linked fibrin in sepsis-induced DIC. | lld:pubmed |
| pubmed-article:21236472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21236472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21236472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21236472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21236472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21236472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21236472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21236472 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21236472 | pubmed:issn | 1879-2472 | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:KashiwakuraYu... | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:SakataYoichiY | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:TanakaHideyuk... | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:OhmoriTsukasa... | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:MadoiwaSeijiS | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:MimuroJunJ | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:YasumotoAtsus... | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:IshiwataAkira... | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:NagahamaYutak... | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:SakataAsukaA | lld:pubmed |
| pubmed-article:21236472 | pubmed:author | pubmed-author:DokaiMomokoM | lld:pubmed |
| pubmed-article:21236472 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21236472 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21236472 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:21236472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21236472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21236472 | pubmed:pagination | 349-55 | lld:pubmed |
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| pubmed-article:21236472 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21236472 | pubmed:articleTitle | Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation. | lld:pubmed |
| pubmed-article:21236472 | pubmed:affiliation | Research Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan. madochan@jichi.ac.jp | lld:pubmed |
| pubmed-article:21236472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21236472 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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