| pubmed-article:21232953 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21232953 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:21232953 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:21232953 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21232953 | lifeskim:mentions | umls-concept:C0667282 | lld:lifeskim |
| pubmed-article:21232953 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21232953 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:21232953 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21232953 | pubmed:dateCreated | 2011-1-24 | lld:pubmed |
| pubmed-article:21232953 | pubmed:abstractText | A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led to the identification of compound 28 is described. | lld:pubmed |
| pubmed-article:21232953 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21232953 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21232953 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21232953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21232953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21232953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21232953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21232953 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21232953 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21232953 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:LavreysenHild... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:LutjensRobert... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:MacdonaldGreg... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:TrabancoAndré... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:PoliSoniaS | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:AndrésJosé... | lld:pubmed |
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| pubmed-article:21232953 | pubmed:author | pubmed-author:DuveyGuillaum... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:PoulainGérald... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:PoirierNicola... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:KarbalaieKK | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:ImogaiHassanH | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:CidJosé... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:NhemVantheaV | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:FurnariRoccoR | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:FinnTerryT | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:RauxAlexandre... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:ThollonYvesY | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:D'AddonaDavid... | lld:pubmed |
| pubmed-article:21232953 | pubmed:author | pubmed-author:RocherJean-Ph... | lld:pubmed |
| pubmed-article:21232953 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21232953 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21232953 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21232953 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21232953 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21232953 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21232953 | pubmed:pagination | 971-6 | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:meshHeading | pubmed-meshheading:21232953... | lld:pubmed |
| pubmed-article:21232953 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21232953 | pubmed:articleTitle | New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones. | lld:pubmed |
| pubmed-article:21232953 | pubmed:affiliation | Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag SA, Toledo, Spain. atrabanc@its.jnj.com | lld:pubmed |
| pubmed-article:21232953 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21232953 | lld:chembl |
