| pubmed-article:21221513 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C0556643 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:21221513 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:21221513 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21221513 | pubmed:dateCreated | 2011-4-19 | lld:pubmed |
| pubmed-article:21221513 | pubmed:abstractText | The p53 tumor suppressor exerts its function mainly as a transcriptional activator. Here we show that the Ras-related small GTPase Rad, an inhibitor of Rho kinase, is a direct transcriptional target of p53. Expression of Rad messenger RNA (mRNA) and protein was induced by DNA damage in a p53-dependent manner. The -2934/-2905-bp Rad promoter region, to which p53 bound, was required for p53-mediated Rad gene activation. Treatment by DNA damaging agents increased p53 occupancy and histone acetylation in the region of Rad promoter containing the p53-binding site. Expression of Rad diminished the inhibitory phosphorylation at Ser3 of cofilin, a regulator of actin dynamics, and suppressed migration and invasiveness of cancer cells. Knockdown of Rad promoted cell migration and alleviated the p53-mediated migration suppression. Frequent loss of Rad mRNA and protein expression was observed in non-small cell lung carcinoma tissues. Together our results reveal a mechanism that p53 may inhibit cell migration by disrupting actin dynamics via Rad activation and implicate a tumor suppressor role of Rad in lung cancer. | lld:pubmed |
| pubmed-article:21221513 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21221513 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21221513 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21221513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21221513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21221513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21221513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21221513 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21221513 | pubmed:month | May | lld:pubmed |
| pubmed-article:21221513 | pubmed:issn | 1432-1440 | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:HsuHan-ShuiHS | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:WuYu-ChungYC | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:WangFung-Fang... | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:ChouTeh-YingT... | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:HsiehPei-Chen... | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:ChenChun-Chin... | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:ChangTsun-Kai... | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:YehYi-ChenYC | lld:pubmed |
| pubmed-article:21221513 | pubmed:author | pubmed-author:HsiaoBo-YuanB... | lld:pubmed |
| pubmed-article:21221513 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21221513 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:21221513 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21221513 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21221513 | pubmed:pagination | 481-92 | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:meshHeading | pubmed-meshheading:21221513... | lld:pubmed |
| pubmed-article:21221513 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21221513 | pubmed:articleTitle | Rad is a p53 direct transcriptional target that inhibits cell migration and is frequently silenced in lung carcinoma cells. | lld:pubmed |
| pubmed-article:21221513 | pubmed:affiliation | Institute of Biochemistry and Molecular Biology, National Yang-Ming University, 155 Li-Nong St., Taipei 112, Taiwan. | lld:pubmed |
| pubmed-article:21221513 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21221513 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
