| pubmed-article:2121579 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2121579 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2121579 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2121579 | lifeskim:mentions | umls-concept:C1522428 | lld:lifeskim |
| pubmed-article:2121579 | lifeskim:mentions | umls-concept:C1160577 | lld:lifeskim |
| pubmed-article:2121579 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:2121579 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2121579 | pubmed:dateCreated | 1990-12-12 | lld:pubmed |
| pubmed-article:2121579 | pubmed:abstractText | The influence of recombinant human interleukins-1 beta and -1 alpha and rat interleukin-1 beta on gastric acid secretion was investigated in awake rats with pylorus ligation. IC injection of either human interleukin-1 beta, human interleukin-1 alpha, or rat interleukin-1 beta induced a dose-dependent inhibition of gastric acid output. At IC doses less than 100 ng, human interleukin-1 beta was more effective than the other forms or sources of interleukin-1, whereas at higher doses (100-500 ng), human interleukins-1 beta and -1 alpha and rat interleukin-1 beta were equipotent. The inhibitory effect was observed 30 minutes after interleukin-1 injection and maintained throughout the 6-hour experimental period. IC injection of interleukin-1 beta inhibited vagally stimulated gastric acid secretion induced by IC injection of the stable thyrotropin-releasing hormone analogue RX 77368. Indomethacin (1, 5, and 10 mg/kg, IP, -30 minutes) induced a dose-related prevention of the inhibitory effect of IC interleukin-1 beta. IC injection of the corticotropin-releasing factor antagonist alpha-CRF9-41, bilateral adrenalectomy, and noradrenergic blockade with bretylium did not influence the antisecretory effect of interleukin-1. Polypeptide action was not related to changes in circulating gastrin levels. Human interleukin-1 beta injected IV also inhibited gastric acid secretion, but the peripheral dose required to induce a significant effect was 10(3)-fold higher than when given centrally. These results show that IC interleukin-1 beta acts centrally to induce a long-lasting inhibition of gastric acid secretion, and this effect requires the integrity of prostaglandin pathways. These data suggest a possible interaction between the immune and gastrointestinal systems. | lld:pubmed |
| pubmed-article:2121579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2121579 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2121579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2121579 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2121579 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2121579 | pubmed:issn | 0016-5085 | lld:pubmed |
| pubmed-article:2121579 | pubmed:author | pubmed-author:RivierCC | lld:pubmed |
| pubmed-article:2121579 | pubmed:author | pubmed-author:TachéYY | lld:pubmed |
| pubmed-article:2121579 | pubmed:author | pubmed-author:YangHH | lld:pubmed |
| pubmed-article:2121579 | pubmed:author | pubmed-author:SaperasE SES | lld:pubmed |
| pubmed-article:2121579 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2121579 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:2121579 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2121579 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2121579 | pubmed:pagination | 1599-606 | lld:pubmed |
| pubmed-article:2121579 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:meshHeading | pubmed-meshheading:2121579-... | lld:pubmed |
| pubmed-article:2121579 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2121579 | pubmed:articleTitle | Central action of recombinant interleukin-1 to inhibit acid secretion in rats. | lld:pubmed |
| pubmed-article:2121579 | pubmed:affiliation | Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles. | lld:pubmed |
| pubmed-article:2121579 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2121579 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2121579 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2121579 | lld:pubmed |
