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pubmed-article:21215755pubmed:dateCreated2011-2-8lld:pubmed
pubmed-article:21215755pubmed:abstractTextThe cardiac action potential (AP) is shaped by myriad ionic currents. In this study, we develop an innovative AP-clamp Sequential Dissection technique to enable the recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell. The ability to measure many currents in a single cell has revealed two hitherto unknown characteristics of the ionic currents in cardiac cells: coordination of currents within a cell and large variation of currents between cells. Hence, the AP-clamp Sequential Dissection method provides a unique and powerful tool for studying individual cell electrophysiology.lld:pubmed
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pubmed-article:21215755pubmed:issn1095-8584lld:pubmed
pubmed-article:21215755pubmed:authorpubmed-author:ZhongJianJlld:pubmed
pubmed-article:21215755pubmed:authorpubmed-author:HorvathBalazs...lld:pubmed
pubmed-article:21215755pubmed:authorpubmed-author:IzuLeighton...lld:pubmed
pubmed-article:21215755pubmed:authorpubmed-author:Chen-IzuYeYlld:pubmed
pubmed-article:21215755pubmed:authorpubmed-author:BanyaszTamasTlld:pubmed
pubmed-article:21215755pubmed:copyrightInfoCopyright © 2010 Elsevier Ltd. All rights reserved.lld:pubmed
pubmed-article:21215755pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21215755pubmed:volume50lld:pubmed
pubmed-article:21215755pubmed:ownerNLMlld:pubmed
pubmed-article:21215755pubmed:authorsCompleteYlld:pubmed
pubmed-article:21215755pubmed:pagination578-81lld:pubmed
pubmed-article:21215755pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:21215755pubmed:year2011lld:pubmed
pubmed-article:21215755pubmed:articleTitleSequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp.lld:pubmed
pubmed-article:21215755pubmed:affiliationDepartment of Pharmacology, University of California, Davis, CA 95616, USA.lld:pubmed
pubmed-article:21215755pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21215755pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:21215755pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed