Linked Life Data

21209461

Source:http://linkedlifedata.com/resource/pubmed/id/21209461

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:21209461rdf:typepubmed:Citationlld:pubmed
pubmed-article:21209461lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C0090388lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C1704675lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C0439851lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C0439855lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C0936012lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C1552596lld:lifeskim
pubmed-article:21209461lifeskim:mentionsumls-concept:C1947931lld:lifeskim
pubmed-article:21209461pubmed:issue12lld:pubmed
pubmed-article:21209461pubmed:dateCreated2011-4-1lld:pubmed
pubmed-article:21209461pubmed:abstractTextCAF-1 is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork. Depletion of CAF-1 from various cell lines causes replication fork arrest, activation of the intra-S phase checkpoint, and global defects in chromatin structure. CAF-1 is also involved in coordinating inheritance of states of gene expression and in chromatin assembly following DNA repair. In this study, we generated cell lines expressing RNAi-resistant versions of CAF-1 and showed that the N-terminal 296 amino acids are dispensable for essential CAF-1 function in vivo. N-terminally truncated CAF-1 p150 was deficient in proliferating cell nuclear antigen (PCNA) binding, reinforcing the existence of two PCNA binding sites in human CAF-1, but the defect in PCNA binding had no effect on the recruitment of CAF-1 to chromatin after DNA damage or to resistance to DNA-damaging agents. Tandem affinity purification of CAF-1-interacting proteins under mild conditions revealed that CAF-1 was directly associated with the KU70/80 complex, part of the DNA-dependent protein kinase, and the phosphoserine/threonine-binding protein 14-3-3 ?. CAF-1 was a substrate for DNA-dependent protein kinase, and the 14-3-3 interaction in vitro is dependent on DNA-dependent protein kinase phosphorylation. These results highlight that CAF-1 has prominent interactions with the DNA repair machinery but that the N terminus is dispensable for the role of CAF-1 in DNA replication- and repair-coupled chromatin assembly.lld:pubmed
pubmed-article:21209461pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:languageenglld:pubmed
pubmed-article:21209461pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:citationSubsetIMlld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21209461pubmed:statusMEDLINElld:pubmed
pubmed-article:21209461pubmed:monthMarlld:pubmed
pubmed-article:21209461pubmed:issn1083-351Xlld:pubmed
pubmed-article:21209461pubmed:authorpubmed-author:StillmanBruce...lld:pubmed
pubmed-article:21209461pubmed:authorpubmed-author:HoekMaartenMlld:pubmed
pubmed-article:21209461pubmed:authorpubmed-author:MyersMichael...lld:pubmed
pubmed-article:21209461pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21209461pubmed:day25lld:pubmed
pubmed-article:21209461pubmed:volume286lld:pubmed
pubmed-article:21209461pubmed:ownerNLMlld:pubmed
pubmed-article:21209461pubmed:authorsCompleteYlld:pubmed
pubmed-article:21209461pubmed:pagination10876-87lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:meshHeadingpubmed-meshheading:21209461...lld:pubmed
pubmed-article:21209461pubmed:year2011lld:pubmed
pubmed-article:21209461pubmed:articleTitleAn analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins.lld:pubmed
pubmed-article:21209461pubmed:affiliationCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.lld:pubmed
pubmed-article:21209461pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21209461pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
entrez-gene:2547entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:5111entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:5591entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:7520entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:7529entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:7534entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:10971entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:23468entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:2969entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:3148entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:4841entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:5935entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:6188entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:6203entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:6418entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:8125entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:8663entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:10036entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:10541entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:26121entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:51428entrezgene:pubmedpubmed-article:21209461lld:entrezgene
entrez-gene:54623entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:21209461lld:entrezgene