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pubmed-article:21208424pubmed:abstractTextDesign of tumour specific immunotherapies using the patients' own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today's gold standard for maturation is a cytokine cocktail consisting of IL-1?, IL-6, TNF-? and PGE2 generating cells lacking IL-12p70 production. OK432 is an immunotherapeutic agent derived from killed Streptococcus pyogenes that has been used clinically to treat malignant and benign neoplasms for decades.lld:pubmed
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pubmed-article:21208424pubmed:articleTitleMaturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses.lld:pubmed
pubmed-article:21208424pubmed:affiliationThe Gade Institute, University of Bergen, Norway.lld:pubmed
pubmed-article:21208424pubmed:publicationTypeJournal Articlelld:pubmed
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