Linked Life Data

21204901

Source:http://linkedlifedata.com/resource/pubmed/id/21204901

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pubmed-article:21204901pubmed:dateCreated2011-2-8lld:pubmed
pubmed-article:21204901pubmed:abstractTextProlonged antiretroviral treatment (ART) significantly changes the cytokine secretion capacities of HIV-1-specific T cells. However, it is unclear whether these changes result from decreased viremia or they correspond to true functional recovery of viral-specific immune response. To study this issue, we analysed the quantitative and qualitative differences of HIV-1-specific and polyclonal CD4+ and CD8+ T cells between 26 naive and 52 treated individuals. HIV-1 Gag and staphylococcal enterotoxin B (SEB)-reactive T cells were determined by flowcytometric intracellular secretion of IFN-? or/and ?L-2. ART resulted in increase of single IL-2 and decrease of single IFN-?-secreting HIV-1 CD4+ T cells, while both cytokines secreting HIV-1 CD4+ T cells were presented in comparable frequencies in both groups. Viral loads correlated negatively with single IL-2 and positively with single IFN-?-secreting HIV-1 CD4+ cells. Single IL-2 HIV-1 CD4+ T cells correlated positively with both cytokines secreting polyclonal CD8+ T cells. By qualitative analysis, a dominant IL-2 HIV-1 CD4+ T cell response (> 70% single IL-2) was identified only in ART suppressed patients, who also generated increased dual specific polyclonal CD8+ T cells. Polyfunctional HIV-1 CD4+ T cell responses were detected even in naive individuals with high viremia. In conclusion, the presence of dominant IL-2 HIV-1 CD4+ T cell response, associated with increased CD8+ T cells capable to produce IL-2, indicates that the recovery of HIV-1-specific CD4+ T cell functionality under ART is a feasible goal. Furthermore, polyfunctional HIV-1 CD4+ T cell responses seem not to be directly involved in viral replication control.lld:pubmed
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pubmed-article:21204901pubmed:authorpubmed-author:TsalimalmaKKlld:pubmed
pubmed-article:21204901pubmed:authorpubmed-author:Choremi-Papad...lld:pubmed
pubmed-article:21204901pubmed:copyrightInfo© 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.lld:pubmed
pubmed-article:21204901pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21204901pubmed:volume73lld:pubmed
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pubmed-article:21204901pubmed:pagination256-65lld:pubmed
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pubmed-article:21204901pubmed:year2011lld:pubmed
pubmed-article:21204901pubmed:articleTitleAntiretroviral therapy-induced dominant interleukin-2 HIV-1 Gag CD4+ T cell response: evidence of functional recovery of HIV-1-specific CD4+ T cells.lld:pubmed
pubmed-article:21204901pubmed:affiliationImmunology Department, General Hospital Athens "LAIKO", Athens, Greece. tsalimalma@hotmail.comlld:pubmed
pubmed-article:21204901pubmed:publicationTypeJournal Articlelld:pubmed