Linked Life Data

21195353

Source:http://linkedlifedata.com/resource/pubmed/id/21195353

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:21195353rdf:typepubmed:Citationlld:pubmed
pubmed-article:21195353lifeskim:mentionsumls-concept:C0028754lld:lifeskim
pubmed-article:21195353lifeskim:mentionsumls-concept:C0027882lld:lifeskim
pubmed-article:21195353lifeskim:mentionsumls-concept:C0023816lld:lifeskim
pubmed-article:21195353lifeskim:mentionsumls-concept:C0011155lld:lifeskim
pubmed-article:21195353lifeskim:mentionsumls-concept:C0597987lld:lifeskim
pubmed-article:21195353lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:21195353lifeskim:mentionsumls-concept:C0181586lld:lifeskim
pubmed-article:21195353pubmed:issue1lld:pubmed
pubmed-article:21195353pubmed:dateCreated2011-1-3lld:pubmed
pubmed-article:21195353pubmed:abstractTextFree fatty acids (FFAs) suppress appetite when injected into the hypothalamus. To examine whether lipoprotein lipase (LPL), a serine hydrolase that releases FFAs from circulating triglyceride (TG)-rich lipoproteins, might contribute to FFA-mediated signaling in the brain, we created neuron-specific LPL-deficient mice. Homozygous mutant (NEXLPL-/-) mice were hyperphagic and became obese by 16 weeks of age. These traits were accompanied by elevations in the hypothalamic orexigenic neuropeptides, AgRP and NPY, and were followed by reductions in metabolic rate. The uptake of TG-rich lipoprotein fatty acids was reduced in the hypothalamus of 3-month-old NEXLPL-/- mice. Moreover, deficiencies in essential fatty acids in the hypothalamus were evident by 3 months, with major deficiencies of long-chain n-3 fatty acids by 12 months. These results indicate that TG-rich lipoproteins are sensed in the brain by an LPL-dependent mechanism and provide lipid signals for the central regulation of body weight and energy balance.lld:pubmed
pubmed-article:21195353pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:languageenglld:pubmed
pubmed-article:21195353pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:citationSubsetIMlld:pubmed
pubmed-article:21195353pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:21195353pubmed:statusMEDLINElld:pubmed
pubmed-article:21195353pubmed:monthJanlld:pubmed
pubmed-article:21195353pubmed:issn1932-7420lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:WangHongHlld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:GoldbergIra...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:EckelRobert...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:NaveKlaus-Arm...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:PiomelliDanie...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:DiPatrizioNic...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:AstaritaGiuse...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:BharadwajKaly...lld:pubmed
pubmed-article:21195353pubmed:authorpubmed-author:TaussigMatthe...lld:pubmed
pubmed-article:21195353pubmed:copyrightInfoCopyright © 2011 Elsevier Inc. All rights reserved.lld:pubmed
pubmed-article:21195353pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21195353pubmed:day5lld:pubmed
pubmed-article:21195353pubmed:volume13lld:pubmed
pubmed-article:21195353pubmed:ownerNLMlld:pubmed
pubmed-article:21195353pubmed:authorsCompleteYlld:pubmed
pubmed-article:21195353pubmed:pagination105-13lld:pubmed
pubmed-article:21195353pubmed:dateRevised2011-10-6lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:meshHeadingpubmed-meshheading:21195353...lld:pubmed
pubmed-article:21195353pubmed:year2011lld:pubmed
pubmed-article:21195353pubmed:articleTitleDeficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.lld:pubmed
pubmed-article:21195353pubmed:affiliationDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Denver Anschutz Medical Campus, Aurora, CO 80045, USA.lld:pubmed
pubmed-article:21195353pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21195353pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:21195353pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
entrez-gene:11922entrezgene:pubmedpubmed-article:21195353lld:entrezgene
entrez-gene:16956entrezgene:pubmedpubmed-article:21195353lld:entrezgene