| pubmed-article:21194191 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0010558 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0031916 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0010467 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0011953 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:21194191 | lifeskim:mentions | umls-concept:C0596448 | lld:lifeskim |
| pubmed-article:21194191 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21194191 | pubmed:dateCreated | 2011-2-3 | lld:pubmed |
| pubmed-article:21194191 | pubmed:abstractText | Diamide linked ?-cyclodextrin (?-CD) dimers are used to capture curcumin and suppress its decomposition in water. In this study, succinamide and urea linked ?-CD dimers joined through the C6(A) carbon on each ?-CD are used. The ?-CD dimers, 66?CD(2)su and 66?CD(2)ur, show a remarkable ability to suppress the decomposition of curcumin and extend its half-life from less than 30 min to greater than 16 h. The 1:1 association of curcumin with 66?CD(2)su and 66?CD(2)ur has high stability constants of 8.7 × 10(6) M(-1) and 2.0 × 10(6) M(-1), respectively. In addition, 2D (1)H NOESY NMR results show specific hydrogen interactions in the association of curcumin with 66?CD(2)su and 66?CD(2)ur, consistent with the cooperative binding of curcumin by both ?-CD annuli of 66?CD(2)su and 66?CD(2)ur. The interactions between curcumin in the linked ?-CD dimers and surfactant micelles were studied using fluorescence spectroscopy. While linked ?-CD dimer-bound curcumin has a negligible fluorescence quantum yield, a significant increase in fluorescence intensity (?(fl) > 2%) in the presence of micelles suggests that curcumin is delivered to the micelle. The overall results indicate that the diamide linked ?-CD dimers are highly promising systems for curcumin delivery in vivo due to effective curcumin stabilization. | lld:pubmed |
| pubmed-article:21194191 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21194191 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21194191 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21194191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21194191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21194191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21194191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21194191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21194191 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21194191 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21194191 | pubmed:issn | 1520-5207 | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:LincolnStephe... | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:EastonChristo... | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:KeeTak WTW | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:LeungMandy... | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:HaradaTakaaki... | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:PhamDuc-TrucD... | lld:pubmed |
| pubmed-article:21194191 | pubmed:author | pubmed-author:NgoHuy TienHT | lld:pubmed |
| pubmed-article:21194191 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21194191 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:21194191 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:21194191 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21194191 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21194191 | pubmed:pagination | 1268-74 | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:meshHeading | pubmed-meshheading:21194191... | lld:pubmed |
| pubmed-article:21194191 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21194191 | pubmed:articleTitle | Cooperative binding and stabilization of the medicinal pigment curcumin by diamide linked ?-cyclodextrin dimers: a spectroscopic characterization. | lld:pubmed |
| pubmed-article:21194191 | pubmed:affiliation | Department of Chemistry, University of Adelaide, Adelaide, South Australia, Australia. | lld:pubmed |
| pubmed-article:21194191 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21194191 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
