Linked Life Data

21193028

Source:http://linkedlifedata.com/resource/pubmed/id/21193028

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pubmed-article:21193028pubmed:abstractTextDopamine cellular signaling via the D(1) receptor (D(1)R) involves both protein kinase A (PKA) and protein kinase C (PKC), but the PKC isoform involved has not been determined. Therefore, we tested the hypothesis that the D(1)R-mediated inhibition of NADPH oxidase activity involves cross talk between PKA and a specific PKC isoform(s). In HEK-293 cells heterologously expressing human D(1)R (HEK-hD(1)), fenoldopam, a D(1)R agonist, and phorbol 12-myristate 13-acetate (PMA), a PKC activator, inhibited oxidase activity in a time- and concentration-dependent manner. The D(1)R-mediated inhibition of oxidase activity (68.1±3.6%) was attenuated by two PKA inhibitors, H89 (10?mol/L; 88±8.1%) and Rp-cAMP (10?mol/L; 97.7±6.7%), and two PKC inhibitors, bisindolylmaleimide I (1?mol/L; 94±6%) and staurosporine (10nmol/L; 93±8%), which by themselves had no effect (n=4-8/group). The inhibitory effect of PMA (1?mol/L) on oxidase activity (73±3.2%) was blocked by H89 (100±7.8%; n=5 or 6/group). The PMA-mediated inhibition of NADPH oxidase activity was accompanied by an increase in PKC?(S676), an effect that was also blocked by H89. Fenoldopam (1?mol/L) also increased PKC?(S676) in HEK-hD(1) and human renal proximal tubule (RPT) cells. Knockdown of PKC? with siRNA in RPT cells prevented the inhibitory effect of fenoldopam on NADPH oxidase activity. Our studies demonstrate for the first time that cross talk between PKA and PKC? plays an important role in the D(1)R-mediated negative regulation of NADPH oxidase activity in human kidney cells.lld:pubmed
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pubmed-article:21193028pubmed:authorpubmed-author:JosePedro APAlld:pubmed
pubmed-article:21193028pubmed:authorpubmed-author:FelderRobin...lld:pubmed
pubmed-article:21193028pubmed:authorpubmed-author:QuinnMark TMTlld:pubmed
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pubmed-article:21193028pubmed:authorpubmed-author:LiHewangHlld:pubmed
pubmed-article:21193028pubmed:authorpubmed-author:YuPeiyingPlld:pubmed
pubmed-article:21193028pubmed:authorpubmed-author:VillarVan...lld:pubmed
pubmed-article:21193028pubmed:authorpubmed-author:HanWeixingWlld:pubmed
pubmed-article:21193028pubmed:authorpubmed-author:ArnaldoFranci...lld:pubmed
pubmed-article:21193028pubmed:copyrightInfoCopyright © 2010 Elsevier Inc. All rights reserved.lld:pubmed
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pubmed-article:21193028pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:21193028pubmed:year2011lld:pubmed
pubmed-article:21193028pubmed:articleTitleDopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk.lld:pubmed
pubmed-article:21193028pubmed:affiliationCenter for Molecular Physiology Research, Children's National Medical Center, Department of Pediatrics, George Washington University School of Medicine, Washington, DC 20010, USA. pyu@cnmc.orglld:pubmed
pubmed-article:21193028pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21193028pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed