| pubmed-article:21187433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21187433 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:21187433 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:21187433 | lifeskim:mentions | umls-concept:C0539788 | lld:lifeskim |
| pubmed-article:21187433 | lifeskim:mentions | umls-concept:C2611279 | lld:lifeskim |
| pubmed-article:21187433 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:21187433 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21187433 | pubmed:dateCreated | 2011-1-12 | lld:pubmed |
| pubmed-article:21187433 | pubmed:abstractText | Dietary absorption is a major way for mammals to obtain cholesterol, which is mediated by Niemann-Pick C1-like 1 (NPC1L1) via vesicular endocytosis. One fundamental question in this process is how free cholesterol is efficiently taken up through the internalization of NPC1L1. Using exogenously expressed NPC1L1-EGFP, we show that the lipid raft proteins flotillins associate with NPC1L1 and their localization is regulated by NPC1L1 during intracellular trafficking. Furthermore, flotillins are essential for NPC1L1-mediated cellular cholesterol uptake, biliary cholesterol reabsorption, and the regulation of lipid levels in mice. Together with NPC1L1, they form cholesterol-enriched membrane microdomains, which function as carriers for bulk of cholesterol. The hypocholesterolemic drug ezetimibe disrupts the association between NPC1L1 and flotillins, which blocks the formation of the cholesterol-enriched microdomains. Our findings reveal a functional role of flotillins in NPC1L1-mediated cholesterol uptake and elucidate the formation of NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption. | lld:pubmed |
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| pubmed-article:21187433 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:21187433 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21187433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21187433 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21187433 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:YuY FYF | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:WangLi-JuanLJ | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:LiBo-LiangBL | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:SongBao-Liang... | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:MiaoHong-HuaH... | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:LiangGeG | lld:pubmed |
| pubmed-article:21187433 | pubmed:author | pubmed-author:QuYu-XiuYX | lld:pubmed |
| pubmed-article:21187433 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21187433 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:21187433 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:21187433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21187433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21187433 | pubmed:pagination | 551-6 | lld:pubmed |
| pubmed-article:21187433 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:21187433 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21187433 | pubmed:articleTitle | Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. | lld:pubmed |
| pubmed-article:21187433 | pubmed:affiliation | State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China. | lld:pubmed |
| pubmed-article:21187433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21187433 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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