| pubmed-article:21177287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C1414995 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C0920563 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:21177287 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:21177287 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21177287 | pubmed:dateCreated | 2011-3-1 | lld:pubmed |
| pubmed-article:21177287 | pubmed:abstractText | Transcriptional regulation of small intestinal gene expression controls plasma total cholesterol (TC) and triglyceride (TG) levels, which are major determinants of metabolic diseases. GATA4, a zinc finger domain transcription factor, is critical for jejunal identity, and intestinal GATA4 deficiency leads to a jejunoileal transition. Although intestinal GATA4 ablation is known to misregulate jejunal gene expression, its pathophysiological impact on various components of metabolic syndrome remains unknown. Here, we used intestine-specific GATA4 knockout (GATA4iKO) mice to dissect the contribution of GATA4 on obesity development. We challenged adult GATA4iKO mice and control littermates with a Western-type diet (WTD) for 20 wk. Our findings show that WTD-fed GATA4iKO mice are resistant to diet-induced obesity. Accordingly, plasma TG and TC levels are markedly decreased. Intestinal lipid absorption in GATA4iKO mice was strongly reduced, whereas luminal lipolysis was unaffected. GATA4iKO mice displayed a greater glucagon-like peptide-1 (GLP-1) release on normal chow and even after long-term challenge with WTD remained glucose sensitive. In summary, our findings show that the absence of intestinal GATA4 has a beneficial effect on decreasing intestinal lipid absorption causing resistance to hyperlipidemia and obesity. In addition, we show that increased GLP-1 release in GATA4iKO mice decreases the risk for development of insulin resistance. | lld:pubmed |
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| pubmed-article:21177287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21177287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21177287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21177287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21177287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21177287 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21177287 | pubmed:issn | 1522-1555 | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:SattlerWolfga... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:Levak-FrankSa... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:KratkyDagmarD | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:HeinemannAkos... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:PfeiferThomas... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:StollbergerRu... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:HoeflerGerald... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:BattleMichele... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:ChandakPrakas... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:DuncanStephen... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:DiwokyClemens... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:ObrowskySasch... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:PatankarJay... | lld:pubmed |
| pubmed-article:21177287 | pubmed:author | pubmed-author:UellenAndreas... | lld:pubmed |
| pubmed-article:21177287 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21177287 | pubmed:volume | 300 | lld:pubmed |
| pubmed-article:21177287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21177287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21177287 | pubmed:pagination | E478-88 | lld:pubmed |
| pubmed-article:21177287 | pubmed:dateRevised | 2011-9-15 | lld:pubmed |
| pubmed-article:21177287 | pubmed:meshHeading | pubmed-meshheading:21177287... | lld:pubmed |
