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2117397

Source:http://linkedlifedata.com/resource/pubmed/id/2117397

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pubmed-article:2117397pubmed:abstractTextOne of the major host-defense functions of alveolar macrophages is the phagocytosis and clearance of inhaled particles deposited in the lower airways and alveolar spaces. Recent studies have indicated that the condensed tannins present in cotton mill dust stimulate the secretion of neutrophil chemotactic factor and arachidonic acid from resident rabbit alveolar macrophages and that these responses may contribute to the acute pulmonary inflammatory reaction associated with byssinosis. To characterize further the effect of tannin on macrophage function, the ability of tannin to modulate alveolar macrophage spreading and phagocytosis in vitro was examined. Tannin caused a dose-dependent inhibition of alveolar macrophage spreading with nearly complete inhibition occurring at concentrations of 12.5 micrograms/ml. This inhibitory effect of tannin was not reversed with removal of tannin. Furthermore addition of tannin to previously spread macrophages actively caused the macrophages to round up. Examination of the structure of alveolar macrophages exposed to tannin by scanning and transmission electron microscopy revealed blebs on the surface of the cells and the loss of most of the cellular organelle structure, as compared to control macrophages. Tannin also modulated the ability of the alveolar macrophages to phagocytize unopsonized latex microspheres. The effect of tannin was biphasic. At the lowest concentration examined (3 micrograms/ml), tannin significantly enhanced phagocytosis of the latex microspheres. However, as the concentration was increased, phagocytosis decreased almost exponentially until at 50 micrograms/ml phagocytosis was significantly inhibited compared to control macrophages. These data indicate that tannin present in inhaled cotton mill dust could significantly decrease the ability of resident alveolar macrophages to phagocytize and thereby clear inhaled dust particles. This inhibitory effect would increase the time that particles remain exposed in the lower airway and alveolar spaces and thereby increase the time that potentially toxic compounds in the dust have to exert their biologic effect. This inhibition of macrophage function may therefore contribute to the pathogenesis of byssinosis.lld:pubmed
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pubmed-article:2117397pubmed:authorpubmed-author:RussellJ AJAlld:pubmed
pubmed-article:2117397pubmed:authorpubmed-author:RohrbachM SMSlld:pubmed
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pubmed-article:2117397pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:2117397pubmed:articleTitleInhibition of alveolar macrophage spreading and phagocytosis by cotton bract tannin. A potential mechanism in the pathogenesis of byssinosis.lld:pubmed
pubmed-article:2117397pubmed:affiliationThoracic Diseases Research Unit, Mayo Clinic/Foundation, Rochester, Minnesota 55905.lld:pubmed
pubmed-article:2117397pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2117397pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:2117397pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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