| pubmed-article:21172030 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21172030 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:21172030 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:21172030 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:21172030 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:21172030 | lifeskim:mentions | umls-concept:C0242339 | lld:lifeskim |
| pubmed-article:21172030 | pubmed:dateCreated | 2011-1-17 | lld:pubmed |
| pubmed-article:21172030 | pubmed:abstractText | Type 2 diabetes is associated with significant cardiovascular morbidity and mortality. Although low-density lipoprotein cholesterol levels may be normal in patients with type 2 diabetes, insulin resistance drives a number of changes in lipid metabolism and lipoprotein composition that render low-density lipoprotein cholesterol and other lipoproteins more pathogenic than species found in patients without type 2 diabetes. Dyslipidemia, which affects almost 50% of patients with type 2 diabetes, is a cardiovascular risk factor characterized by elevated triglyceride levels, low high-density lipoprotein cholesterol levels, and a preponderance of small, dense, low-density lipoprotein particles. Early, aggressive pharmacological management is advocated to reduce low-density lipoprotein cholesterol levels, regardless of baseline levels. A number of lipid-lowering agents, including statins, fibrates, niacin, and bile acid sequestrants, are available to target normalization of the entire lipid profile. Despite use of combination and high-dose lipid-lowering agents, many patients with type 2 diabetes do not achieve lipid targets. This review outlines the characteristics and prevalence of dyslipidemia in patients with type 2 diabetes and discusses strategies that may reduce the risk of cardiovascular disease in this population. | lld:pubmed |
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| pubmed-article:21172030 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21172030 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21172030 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21172030 | pubmed:status | MEDLINE | lld:pubmed |
